Abbas AK, Lichtman AH. Basic Immunology: Functions and Disorders of the Immune System. 3rd ed. Philadelphia, PA: Saunders Elsevier; 2009.
Abe Y, Yuasa M, Kajiwara Y, Hosono M. Defects of immune cells in the senescence-accelerated mouse: a model for learning and memory deficits in the aged. Cell Immunol. Aug 1994;157(1):59-69.
Adams WJ, Morris DL, Ross WB, Lubowski DZ, King DW, Peters L. Cimetidine preserves non-specific immune function after colonic resection for cancer. The Australian and New Zealand journal of surgery. Dec 1994;64(12):847-852.
Adolfsson O, Huber BT, Meydani SN. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. Journal of immunology (Baltimore, Md.: 1950). Oct 1 2001;167(7):3809-3817.
Agarwal S, Busse PJ. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol. Mar 2010;104(3):183-190; quiz 190-182, 210.
Ahmed T, Das SK, Golden JK, Saltzman E, Roberts SB, Meydani SN. Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women. J Gerontol A Biol Sci Med Sci. Nov 2009;64(11):1107-1113.
Aldabal L, Bahammam AS. Metabolic, endocrine, and immune consequences of sleep deprivation. The Open Respiratory Medicine Journal. 2011;5:31-43.
Aleem E. beta-Glucans and their applications in cancer therapy: focus on human studies. Anti-cancer agents in medicinal chemistry. Jun 2013;13(5):709-719.
Ambrosia LLC. ClinicalTrials.gov entry: Young Donor Plasma Transfusion and Age-Related Biomarkers. https://clinicaltrials.gov/ct2/show/NCT02803554?term=young+plasma&rank=2. Accessed 8/12/2016.
Andresen RH, Hass GM, Madden DA, Monroe CW. Postparabiotic tissue reactions of rabbits to musculofascial cross-transplants. J Exp Med. Jan 1 1957;105(1):85-92.
Antoni MH, Lutgendorf SK, Blomberg B, et al. Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biological psychiatry. Feb 15 2012;71(4):366-372.
Aranha I, Clement F, Venkatesh YP. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). Journal of ethnopharmacology. Jan 31 2012;139(2):366-372.
Arndt PA, Garratty G, Brasfield FM, Vemuri SL, Asuncion DJ. Immune hemolytic anemia due to cimetidine: the first example of a cimetidine antibody. Transfusion. Feb 2010;50(2):302-307.
Arvedson T, O'Kelly J, Yang BB. Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor. BioDrugs: clinical immunotherapeutics, biopharmaceuticals and gene therapy. Jun 2015;29(3):185-198.
Avtonomova AV, Krasnopolskaya LM. [Antiviral properties of basidiomycetes metabolites]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR. 2014;59(7-8):41-48.
Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. Apr 2007;120(4):435-446.
Bai D, Yang G, Yuan H, Li Y, Wang K, Shao H. Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. 1999;19(4):300-303.
Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. Nov 10 2011;479(7372):232-236.
Bala M, Pratap K, Verma PK, Singh B, Padwad Y. Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. Journal of ethnopharmacology. Dec 4 2015;175:131-137.
Bala M, Verma PK, Awasthi S, Kumar N, Lal B, Singh B. Chemical prospection of important ayurvedic plant Tinospora cordifolia by UPLC-DAD-ESI-QTOF-MS/MS and NMR. Natural product communications.Jan 2015;10(1):43-48.
Bales CW, Kraus WE. Caloric restriction: implications for human cardiometabolic health. J Cardiopulm Rehabil Prev. Jul-Aug 2013;33(4):201-208.
Bao B, Prasad AS, Beck FW, et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American journal of clinical nutrition. Jun 2010;91(6):1634-1641.
Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. International journal of medicinal mushrooms. 2013;15(2):127-143.
Bauer ME. Chronic stress and immunosenescence: a review. Neuroimmunomodulation. 2008;15(4-6):241-250.
Bauer ME, Wieck A, Petersen LE, Baptista TS. Neuroendocrine and viral correlates of premature immunosenescence. Annals of the New York Academy of Sciences. Sep 2015;1351:11-21.
Belcaro G, Cesarone MR, Cornelli U, et al. Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study. Panminerva Med. Dec 2010;52(4):269-275.
Beli E, Duriancik DM, Clinthorne JF, Lee T, Kim S, Gardner EM. Natural killer cell development and maturation in aged mice. Mechanisms of ageing and development. Jan 2014;135:33-40.
Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nature reviews. Immunology. 2007;7(11):875-888.
Bendall LJ, Bradstock KF. G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent. Cytokine and Growth Factor Reviews. 2014;25(4):355-367.
Bert P. J Anatomie Physiologie. 1864;1:69–87.
Bollinger T, Bollinger A, Skrum L, Dimitrov S, Lange T, Solbach W. Sleep-dependent activity of T cells and regulatory T cells. Clinical and experimental immunology. Feb 2009;155(2):231-238.
Bosch JA, Fischer JE, Fischer JC. Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence. Brain Behav Immun. May 2009;23(4):527-534.
Brender E, Lynm C, Glass RM. GRanulocyte-colony stimulating factor. JAMA. 2006;295(9):1088-1088.
Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. The Journal of nutrition. Jun 2006;136(6 Suppl):1636s-1640s.
Buford TW, Willoughby DS. Impact of DHEA(S) and cortisol on immune function in aging: a brief review. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Jun 2008;33(3):429-433.
Buoso E, Lanni C, Molteni E, Rousset F, Corsini E, Racchi M. Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor for Activated C Kinase 1: implications in immunosenescence. Experimental gerontology. Nov 2011;46(11):877-883.
Butcher S, Chahel H, Lord JM. Ageing and the neutrophil: no appetite for killing? Immunology. 2000;100(4):411-416.
Butterfield DA, Poon HF. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Experimental gerontology. Oct 2005;40(10):774-783.
Cabrera AJ. Zinc, aging, and immunosenescence: an overview. Pathobiol Aging Age Relat Dis. 2015;5:25592.
Caccavo D, Pellegrino NM, Altamura M, Rigon A, Amati L, Amoroso A, Jirillo E. Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application. J Endotoxin Res. 2002;8(6):403-417.
Candore G, Balistreri CR, Colonna-Romano G, et al. Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res. Apr 2008;11(2):425-432.
Cannizzo ES, Clement CC, Sahu R, Follo C, Santambrogio L. Oxidative stress, inflamm-aging and immunosenescence. Journal of proteomics. Oct 19 2011;74(11):2313-2323.
Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ. Dysbiosis of the gut microbiota in disease. Microbial ecology in health and disease. 2015;26:26191.
Carlson LE, Speca M, Faris P, Patel KD. One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun. Nov 2007;21(8):1038-1049.
Carroll JE, Cole SW, Seeman TE, et al. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun. Jan 2016;51:223-229.
Casas R, Sacanella E, Estruch R. The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases. Endocrine, metabolic & immune disorders drug targets. 2014;14(4):245-254.
Castelo-Branco C, Soveral I. The immune system and aging: a review. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. Jan 2014;30(1):16-22.
CDC. Centers for Disease Control and Prevention. Cytomegalovirus (CMV) and Congenital CMV Infection. http://www.cdc.gov/cmv/overview.html. Last updated 6/17/2016a. Accessed 12/12/2016.
CDC. Centers for Disease Control and Prevention. Cytomegalovirus (CMV) and Congenital CMV Infection. Interpretation of Lab Tests. http://www.cdc.gov/cmv/clinical/lab-tests.html. Last updated 6/17/2016b. Accessed 8/16/2016.
Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. Journal of hematology & oncology. 2009;2:25.
Chaplin DD. Overview of the immune response. The Journal of allergy and clinical immunology. Feb 2010;125(2 Suppl 2):S3-23.
Chen J, Seviour R. Medicinal importance of fungal beta-(1-->3), (1-->6)-glucans. Mycological research. Jun 2007;111(Pt 6):635-652.
Chen W, Zhang Y, Tan N, Qi Y, Zhu J-S. Synergy of Ganoderma lucidum Extract ReishiMax and Green Tea Polyphenols Tegreen in Anti-Cancer in a S180-inoculation model. The FASEB Journal. 2007;21(6):A1100.
Choi JY, Paik DJ, Kwon DY, Park Y. Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-gamma activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. Nutrition journal. 2014;13:35.
Cholujova D, Jakubikova J, Czako B, et al. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer immunology, immunotherapy: CII. Mar 2013;62(3):437-445.
Cholujova D, Jakubikova J, Sedlak J. BioBran-augmented maturation of human monocyte-derived dendritic cells. Neoplasma. 2009;56(2):89-95.
Chou JP, Effros RB. T cell replicative senescence in human aging. Current pharmaceutical design. 2013;19(9):1680-1698.
Chu SL, Fu H, Yang JX, et al. A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome. Chin J Integr Med. Jul 2011;17(7):492-498.
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760–764.
Corsini E, Racchi M, Sinforiani E, et al. Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone. Journal of leukocyte biology. Feb 2005;77(2):247-256.
Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, Yatomi-Clarke SL, Robinson AP. CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool? J Transl Med. 2009;7:102.
Dalonso N, Goldman GH, Gern RM. beta-(1-->3),(1-->6)-Glucans: medicinal activities, characterization, biosynthesis and new horizons. Appl Microbiol Biotechnol. Oct 2015;99(19):7893-7906.
Danenberg HD, Ben-Yehuda A, Zakay-Rones Z, Friedman G. Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine. 1995;13(15):1445-1448.
de Araujo AL, Silva LC, Fernandes JR, Benard G. Preventing or reversing immunosenescence: can exercise be an immunotherapy? Immunotherapy. Aug 2013;5(8):879-893.
de Brouwer SJ, van Middendorp H, Kraaimaat FW, et al. Immune responses to stress after stress management training in patients with rheumatoid arthritis. Arthritis research & therapy. 2013;15(6):R200.
De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. The European respiratory journal. Jul 1997;10(7):1535-1541.
De la Fuente M, Hernanz A, Guayerbas N, Victor VM, Arnalich F. Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research. Mar 2008;42(3):272-280.
de Moreno de LeBlanc A, Matar C, Perdigon G. The application of probiotics in cancer. The British journal of nutrition. Oct 2007;98 Suppl 1:S105-110.
Delves PJ. Components of the Immune System. Merck Manual - Professional Version http://www.merckmanuals.com/professional/immunology-allergic-disorders/biology-of-the-immune-system/components-of-the-immune-system. Last updated 11/2014. Accessed September 24, 2015.
Derhovanessian E, Maier AB, Beck R, et al. Hallmark features of immunosenescence are absent in familial longevity. J Immunol. Oct 15 2010;185(8):4618-4624.
Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunol Res. May 2014;58(2-3):193-210.
Dimeloe S, Nanzer A, Ryanna K, Hawrylowicz C. Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D. The Journal of steroid biochemistry and molecular biology.May 31 2010;120(2-3):86-95.
Dionysius DA, Grieve PA, Milne JM. Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli. J Dairy Sci. Sep 1993;76(9):2597-2600.
Dock JN, Effros RB. Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence. Aging Dis. Oct 2011;2(5):382-397.
Drake VJ. Linus Pauling Institute. Overview of the Immune System. http://lpi.oregonstate.edu/mic/micronutrients-health/immunity. Last updated 8/2010. Accessed September 24, 2015.
Drela N, Kozdron E, Szczypiorski P. Moderate exercise may attenuate some aspects of immunosenescence. BMC geriatrics. Sep 29 2004;4:8.
Du Clos TW, Mold C. C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity. Immunol Res. 2004;30(3):261-277.
Duarte PO, Duarte MG, Pelichek A, Pfrimer K, Ferriolli E, Moriguti JC, Lima NK. Cardiovascular risk factors and inflammatory activity among centenarians with and without dementia. Aging Clin Exp Res. Jul 4 2016.
Duncan SH, Flint HJ. Probiotics and prebiotics and health in ageing populations. Maturitas. May 2013;75(1):44-50.
Ebrahimi M, Mohammad Hassan Z, Mostafaie A, Zare Mehrjardi N, Ghazanfari T. Purif ied Protein Fraction of Garlic Extract Modulates Cellular Immune Response against Breast Transplanted Tumors in BALB/c Mice Model. Cell journal. Spring 2013;15(1):65-75.
Eom CS, Jeon CY, Lim JW, Cho EG, Park SM, Lee KS. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne. Feb 22 2011;183(3):310-319.
Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annual review of medicine. 2000;51:245-270.
Estruch R. Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study. Proc Nutr Soc. Aug 2010;69(3):333-340.
Fernandes G, Venkatraman JT, Turturro A, Attwood VG, Hart RW. Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats. Journal of clinical immunology. Jan 1997;17(1):85-95.
Fessler J, Ficjan A, Duftner C, Dejaco C. The impact of aging on regulatory T-cells. Frontiers in immunology. 2013;4:231.
Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A. Gut microbiota and metabolic syndrome. World journal of gastroenterology: WJG. 2014;20(43):16079-16094.
Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proceedings of the National Academy of Sciences of the United States of America. Apr 27 2004;101(17):6659-6663.
Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. Jun 2014;69 Suppl 1:S4-9.
Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mechanisms of ageing and development. Feb 2005;126(2):351-361.
Freeman SL, Fisher L, German JB, et al. Dairy proteins and the response to pneumovax in senior citizens: a randomized, double-blind, placebo-controlled pilot study. Annals of the New York Academy of Sciences. Mar 2010;1190:97-103.
Fu G, Pang H, Wong YH. Naturally occurring phenylethanoid glycosides: potential leads for new therapeutics. Current medicinal chemistry. 2008;15(25):2592-2613.
Ganz FD. Sleep and immune function. Critical care nurse. Apr 2012;32(2):e19-25.
Garbers C, Kuck F, Aparicio-Siegmund S, et al. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell cycle (Georgetown, Tex.). Nov 1 2013;12(21):3421-3432.
Ghazanfari T, Hassan ZM, Ebtekar M, Ahmadiani A, Naderi G, Azar A. Garlic induces a shift in cytokine pattern in Leishmania major-infected BALB/c mice. Scandinavian journal of immunology. Nov 2000;52(5):491-495.
Ghezzi P. Role of glutathione in immunity and inflammation in the lung. International journal of general medicine. 2011;4:105-113.
Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). The Journal of pharmacy and pharmacology. Dec 2004;56(12):1581-1588.
Ghoneum M, Agrawal S. Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. International journal of immunopathology and pharmacology. Oct-Dec 2014;27(4):523-530.
Ghoneum M, Badr El-Din NK, Abdel Fattah SM, Tolentino L. Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body gamma-irradiation in mice via restoration of hematopoietic tissues. Journal of radiation research. May 2013;54(3):419-429.
Ghoneum M, Badr El-Din NK, Ali DA, El-Dein MA. Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer research. Jan 2014;34(1):81-87.
Ghoneum M, Gollapudi S. Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro. Neoplasma. 2011;58(2):118-123.
Ghoneum M, Matsuura M. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). International journal of immunopathology and pharmacology. Sep-Dec 2004;17(3):283-292.
Ghoneum M, Matsuura M, Gollapudi S. Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro. International journal of immunopathology and pharmacology. Jan-Mar 2008;21(1):87-95.
Ghosh T, Auerochs S, Saha S, Ray B, Marschall M. Anti-cytomegalovirus activity of sulfated glucans generated from a commercial preparation of rice bran. Antiviral chemistry & chemotherapy. 2010;21(2):85-95.
Gifford RR, Voss BV, Schmidtke JR, Ferguson RM. Histamine type-2 receptor antagonist immune modulation. I. Increased cell-mediated cytotoxicity in normal and in down-regulated systems. Surgery. Feb 1988;103(2):184-192.
Gleeson M, Williams C. Intense exercise training and immune function. Nestle Nutrition Institute workshop series. 2013;76:39-50.
Gold Standard. Drug Monograph. Filgrastim, G-CSF. www.clinicalkey.com. Last updated 3/7/2016. Accessed 8/16/2016.
Gomez CR, Karavitis J, Palmer JL, Faunce DE, Ramirez L, Nomellini V, Kovacs EJ. Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm. 2010;2010:475139.
Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013;14(5):428-436.
Graf D, Di Cagno R, Fak F, Flint HJ, Nyman M, Saarela M, Watzl B. Contribution of diet to the composition of the human gut microbiota. Microbial ecology in health and disease. 2015;26:26164.
Griffith AV, Venables T, Shi J, et al. Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency. Cell reports. Aug 18 2015;12(7):1071-1079.
Grubeck-Loebenstein B, Della Bella S, Iorio AM, Michel JP, Pawelec G, Solana R. Immunosenescence and vaccine failure in the elderly. Aging Clin Exp Res. Jun 2009;21(3):201-209.
Haase H, Rink L. The immune system and the impact of zinc during aging. Immunity & ageing: I & A. 2009;6:9.
Hahm KB, Kim WH, Lee SI, Kang JK, Park IS. Comparison of immunomodulative effects of the histamine-2 receptor antagonists cimetidine, ranitidine, and famotidine on peripheral blood mononuclear cells in gastric cancer patients. Scandinavian journal of gastroenterology. Mar 1995;30(3):265-271.
Hahm KB, Lee SI, Chung JP, Kim WH, Kim JH, Park IS. Comparison of immunomodulative effects of histamine-2 receptor antagonists in gastric cancer patients: focus on the lymphoblastogenesis and cytotoxicity of peripheral blood mononuclear cells. International journal of immunopharmacology. Dec 1994;16(12):985-993.
Hakim FT, Gress RE. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue antigens. Sep 2007;70(3):179-189.
Han SN, Meydani SN. Impact of vitamin E on immune function and its clinical implications. Expert review of clinical immunology. Jul 2006;2(4):561-567.
Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. The American journal of medicine. May 1999;106(5):506-512.
Hast R, Bernell P, Hansson M. Cimetidine as an immune response modifier. Medical oncology and tumor pharmacotherapy. 1989;6(1):111-113.
Hazeldine J, Lord JM. The impact of ageing on natural killer cell function and potential consequences for health in older adults. Ageing Res Rev. Sep 2013;12(4):1069-1078.
Heidari B. The importance of C-reactive protein and other inflammatory markers in patients with chronic obstructive pulmonary disease. Caspian J Intern Med. Spring 2012;3(2):428-435.
Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. The Cochrane database of systematic reviews. 2013;1:Cd000980.
Hinken AC, Powers JM, Luo G, Holt JA, Billin AN, Russell AJ. Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells. Aging Cell. Jun 2016;15(3):582-584.
Hirai N, Hill NO, Motoo Y, Osther K. Cimetidine enhances interferon induced augmentation of NK cell activity and suppresses interferon production. Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology. Aug 1985;93(4):153-159.
Hirotsu C, Tufik S, Andersen ML. Interactions between sleep, stress, and metabolism: From physiological to pathological conditions. Sleep Science (Sao Paulo, Brazil). Nov 2015;8(3):143-152.
Holmannova D, Kolackova M, Krejsek J. [Vitamin C and its physiological role with respect to the components of the immune system]. Vnitrni lekarstvi. Oct 2012;58(10):743-749.
Homayoni Rad A, Vaghef Mehrabany E, Alipoor B, Vaghef Mehrabany L. The Comparison of Food and Supplement as Probiotic Delivery Vehicles. Critical reviews in food science and nutrition. Apr 25 2016;56(6):896-909.
Homayouni Rad A, Torab R, Ghalibaf M, Norouzi S, Mehrabany EV. Might patients with immune-related diseases benefit from probiotics? Nutrition (Burbank, Los Angeles County, Calif.). Mar 2013;29(3):583-586.
Horrington EM, Pope F, Lunsford W, Mc CC. Age changes in the bones, blood pressure, and diseases of rats in parabiosis. Gerontologia. 1960;4:21-31.
Iannello A, Raulet DH. Immune surveillance of unhealthy cells by natural killer cells. Cold Spring Harbor symposia on quantitative biology. 2013;78:249-257.
Ibarra-Coronado EG, Pantaleon-Martinez AM, Velazquez-Moctezuma J, et al. The Bidirectional Relationship between Sleep and Immunity against Infections. J Immunol Res. 2015;2015:678164.
Ibrahim F, Ruvio S, Granlund L, Salminen S, Viitanen M, Ouwehand AC. Probiotics and immunosenescence: cheese as a carrier. FEMS immunology and medical microbiology. Jun 1 2010;59(1):53-59.
Iwatsuki K, Akihisa T, Tokuda H, et al. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. Journal of natural products. Dec 2003;66(12):1582-1585.
Jagger A, Shimojima Y, Goronzy JJ, Weyand CM. Regulatory T cells and the immune aging process: a mini-review. Gerontology. 2014;60(2):130-137.
Jain S, Gautam V, Naseem S. Acute-phase proteins: As diagnostic tool. Journal of pharmacy & bioallied sciences. Jan 2011;3(1):118-127.
Jensen GS, Patel D, Benson KF. A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans. Preventive medicine. May 2012;54 Suppl:S124-129.
Ji LL, Wang Z, Dong F, Zhang WB, Wang ZT. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. Journal of cellular biochemistry. Aug 1 2005;95(5):970-978.
Jiang Y, Tu PF. Analysis of chemical constituents in Cistanche species. Journal of chromatography. A. Mar 13 2009;1216(11):1970-1979.
Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q. Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. PloS one. 2014;9(6):e99396.
Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. The Cochrane database of systematic reviews. 2012;6:CD007731.
Jin ZW, Kumar A, Cleveland RP, Murray DL, Kaufman DB. Inhibition of suppressor cell function by cimetidine in a murine model. Clinical immunology and immunopathology. Mar 1986;38(3):350-356.
Jolly CA. Dietary restriction and immune function. The Journal of nutrition. Aug 2004;134(8):1853-1856.
Karmazin J. Ambrosia LLC. Young Donor Plasma Transfusion and Age-Related Biomarkers. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Last updated 2016 Oct. 31. https://clinicaltrials.gov/ct2/show/NCT02803554. NLM Identifier: NCT02803554.
Karrer U, Mekker A, Wanke K, Tchang V, Haeberli L. Cytomegalovirus and immune senescence: culprit or innocent bystander? Experimental gerontology. Nov 2009;44(11):689-694.
Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Fungal beta-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. Journal of immunology (Baltimore, Md.: 1950). Oct 1 2014;193(7):3308-3321.
Katoh J, Tsuchiya K, Osawa H, et al. Cimetidine reduces impairment of cellular immunity after cardiac operations with cardiopulmonary bypass. J Thorac Cardiovasc Surg. Aug 1998;116(2):312-318.
Kent KD, Harper WJ, Bomser JA. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol In Vitro. Feb 2003;17(1):27-33.
Khorram O, Vu L, Yen SS. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A Biol Sci Med Sci. Jan 1997;52(1):M1-7.
Kikuchi Y, Oomori K, Kizawa I, Kato K. Augmented natural killer activity in ovarian cancer patients treated with cimetidine. European journal of cancer & clinical oncology. Sep 1986;22(9):1037-1043.
Kim HY, Kim JH, Yang SB, et al. A polysaccharide extracted from rice bran fermented with Lentinus edodes enhances natural killer cell activity and exhibits anticancer effects. Journal of medicinal food. Mar 2007;10(1):25-31.
Kladar NV, Gavaric NS, Bozin BN. Ganoderma: insights into anticancer effects. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP). Aug 27 2015.
Kloek J, Mortaz E, Van Ark I, Bloksma N, Garssen J, Nijkamp FP, Folkerts G. A whey-based glutathione-enhancing diet decreases allergen-induced airway contraction in a guinea-pig model of asthma. The British journal of nutrition. May 2011;105(10):1465-1470.
Kokhaei P, Barough MS, Hassan ZM. Cimetidine effects on the immunosuppression induced by burn injury. International immunopharmacology. Sep 2014;22(1):273-276.
Komlos L, Notmann J, Arieli J, Hart J, Levinsky H, Halbrecht I, Sendovsky U. IN vitro cell-mediated immune reactions in herpes zoster patients treated with cimetidine. Asian Pac J Allergy Immunol. Jun 1994;12(1):51-58.
Krissansen GW. Emerging health properties of whey proteins and their clinical implications. Journal of the American College of Nutrition. Dec 2007;26(6):713s-723s.
Kroll J. Dehydroepiandrosterone, molecular chaperones and the epigenetics of primate longevity. Rejuvenation Res. Feb 23 2015.
Kubota T, Fujiwara H, Ueda Y, et al. Cimetidine modulates the antigen presenting capacity of dendritic cells from colorectal cancer patients. British journal of cancer. Apr 22 2002;86(8):1257-1261.
Kyo E, Uda N, Kasuga S, Itakura Y. Immunomodulatory effects of aged garlic extract. The Journal of nutrition. Mar 2001;131(3s):1075s-1079s.
Kyo E, Uda N, Ushijima M, Kasuga S, Itakura Y. Prevention of psychological stress-induced immune suppression by aged garlic extract. Phytomedicine: international journal of phytotherapy and phytopharmacology. Nov 1999;6(5):325-330.
Kyung J, Kim D, Park D, et al. Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract. Laboratory animal research. Jun 2012;28(2):91-97.
LabCorp Laboratory Corporation of America. Test Menu. Natural Killer Cell Surface Antigen (CD3-CD56+ Marker Analysis). https://www.labcorp.com/. Accessed November 8, 2015.
Lang PO, Govind S, Aspinall R. Reversing T cell immunosenescence: why, who, and how. Age (Dordrecht, Netherlands). Jun 2013;35(3):609-620.
Lange T, Perras B, Fehm HL, Born J. Sleep enhances the human antibody response to hepatitis A vaccination. Psychosomatic medicine. Sep-Oct 2003;65(5):831-835.
Lee JH, Lee SH, Choi SH, Asahara T, Kwon SM. The sulfated polysaccharide fucoidan rescues senescence of endothelial colony-forming cells for ischemic repair. Stem cells (Dayton, Ohio). Jun 2015;33(6):1939-1951.
Lee LK, Foo KY. Recent advances on the beneficial use and health implications of Pu-Erh tea. Food Research International. 2013;53(2):619-628.
Lefevre M, Racedo SM, Ripert G, et al. Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immunity & ageing: I & A. 2015;12:24.
Lefevre M, Redman LM, Heilbronn LK, et al. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis. Mar 2009;203(1):206-213.
Lefranc F, Yeaton P, Brotchi J, Kiss R. Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review). International journal of oncology. May 2006;28(5):1021-1030.
Legrand D, Pierce A, Elass E, Carpentier M, Mariller C, Mazurier J. Lactoferrin structure and functions. Advances in experimental medicine and biology. 2008;606:163-194.
Li B, Cao F, Zhu Q, Li B, Gan M, Wang D. Perioperative cimetidine administration improves systematic immune response and tumor infiltrating lymphocytes in patients with colorectal cancer. Hepato-gastroenterology. Mar-Apr 2013;60(122):244-247.
Li L, Tsao R, Yang R, Liu C, Young JC, Zhu H. Isolation and purification of phenylethanoid glycosides from Cistanche deserticola by high-speed counter-current chromatography. Food chemistry. 2008;108(2):702-710.
Li YQ, Wang SF. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Biotechnology letters. Jun 2006;28(11):837-841.
Li Z, Liu J, Zhao Y. Possible mechanism underlying the antiherpetic activity of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro. Journal of biochemistry and molecular biology. Jan 31 2005;38(1):34-40.
Licastro F, Porcellini E. Persistent infections, immune-senescence and Alzheimer's disease. Oncoscience. 2016;3(5-6):135-142.
Liu Q, Zhang C, Sun A, Zheng Y, Wang L, Cao X. Tumor-Educated CD11bhighIalow Regulatory Dendritic Cells Suppress T Cell Response through Arginase I. The Journal of Immunology. May 15, 2009 2009;182(10):6207-6216.
Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. May 09 2013;153(4):828-839.
Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. Jun 6 2013;153(6):1194-1217.
Ludwig FE, R. Mortality in syngenic rat parabioints of different chronological age. Transactions of the New York Academy of Sciences. 1972;34(7):582–587.
Luna-Castro S, Aguilar-Romero F, Samaniego-Barron L, Godinez-Vargas D, de la Garza M. Effect of bovine apo-lactoferrin on the growth and virulence of Actinobacillus pleuropneumoniae. Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine. Oct 2014;27(5):891-903.
Lv S, Wu Y, Zhou J, et al. The study of fingerprint characteristics of Dayi Pu-Erh tea using a fully automatic HS-SPME/GC-MS and combined chemometrics method. PloS one. 2014;9(12):e116428.
Ma B, Ren W, Zhou Y, Ma J, Ruan Y, Wen CN. Triterpenoids from the spores of Ganoderma lucidum. North American journal of medical sciences. Nov 2011;3(11):495-498.
Maeda H, Ichihashi K, Fujii T, Omura K, Zhu X, Anazawa M, Tazawa K. Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action. BioFactors (Oxford, England). 2004;21(1-4):185-187.
Maharaj D, Inventor; Advanced Neuroregenerative Therapies, Llc, assignee. Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use. 2014.
Maijo M, Clements SJ, Ivory K, Nicoletti C, Carding SR. Nutrition, diet and immunosenescence. Mechanisms of ageing and development. Mar-Apr 2014;136-137:116-128.
Maranduba CM, De Castro SB, de Souza GT, et al. Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis. J Immunol Res. 2015;2015:931574.
MayoClinic. Mayo Medical Laboratories. Cytomegalovirus (CMV) Antibodies, IgM and IgG, Serum. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62067. Accessed November 8, 2015a.
MayoClinic. Mayo Medical Laboratories. Immunoglobulins (IgG, IgA, and IgM), Serum. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8156. Accessed November 9, 2015b.
Maywald M, Rink L. Zinc homeostasis and immunosenescence. J Trace Elem Med Biol. Jan 2015;29:24-30.
McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G. The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine. Mar 9 2012;30(12):2060-2067.
McGregor BA, Antoni MH, Boyers A, Alferi SM, Blomberg BB, Carver CS. Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer. Journal of psychosomatic research. Jan 2004;56(1):1-8.
McLaughlin B, O'Malley K, Cotter TG. Age-related differences in granulocyte chemotaxis and degranulation. Clinical science (London, England: 1979). Jan 1986;70(1):59-62.
Mekker A, Tchang VS, Haeberli L, Oxenius A, Trkola A, Karrer U. Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS pathogens. 2012;8(8):e1002850.
Mena MP, Sacanella E, Vazquez-Agell M, et al. Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. The American journal of clinical nutrition. Jan 2009;89(1):248-256.
Mendelsohn AR, Larrick JW. Overcoming the aging systemic milieu to restore neural stem cell function. Rejuvenation Res. Dec 2011;14(6):681-684.
Messaoudi I, Warner J, Fischer M, et al. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. Dec 19 2006;103(51):19448-19453.
Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, Hamer DH. Serum zinc and pneumonia in nursing home elderly. The American journal of clinical nutrition. Oct 2007;86(4):1167-1173.
Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L. Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol. Jan 17 2006;47(2):398-402.
Michaelis M, Doerr HW, Cinatl J. The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia (New York, N.Y.). Jan 2009;11(1):1-9.
Michan S. Calorie restriction and NAD(+)/sirtuin counteract the hallmarks of aging. Front Biosci (Landmark Ed). 2014;19:1300-1319.
Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. European journal of clinical investigation. Feb 2001;31(2):171-178.
Millea PJ. N-acetylcysteine: multiple clinical applications. American family physician. Aug 1 2009;80(3):265-269.
Miller A, Harel D, Laor A, Lahat N. Cimetidine as an immunomodulator in the treatment of herpes zoster. J Neuroimmunol. Mar 1989;22(1):69-76.
Mitchell WA, Lang PO, Aspinall R. Tracing thymic output in older individuals. Clinical and experimental immunology. Sep 2010;161(3):497-503.
Modi SR, Collins JJ, Relman DA. Antibiotics and the gut microbiota. The Journal of clinical investigation. Oct 2014;124(10):4212-4218.
Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. The Journal of clinical investigation. Mar 2013;123(3):958-965.
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765.
Morey JN, Boggero IA, Scott AB, Segerstrom SC. Current Directions in Stress and Human Immune Function. Current opinion in psychology. Oct 1 2015;5:13-17.
Muller L, Fulop T, Pawelec G. Immunosenescence in vertebrates and invertebrates. Immunity & ageing: I & A. 2013;10(1):12.
Nagler A, Rozenbaum H, Enat R, Tatarsky I, Katz R, Pollack S. Immune basis for cimetidine-induced pancytopenia. Am J Gastroenterol. Apr 1987;82(4):359-361.
Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. International immunopharmacology. Dec 15 2004;4(13):1645-1659.
Naylor K, Li G, Vallejo AN, et al. The influence of age on T cell generation and TCR diversity. J Immunol. Jun 1 2005;174(11):7446-7452.
Negishi H, Mori M, Mori H, Yamori Y. Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. The Journal of nutrition. Nov 2013;143(11):1794-1798.
NIH. National Heart, Lung, and Blood Institute. Types of Blood Tests. White Blood Cells. http://www.nhlbi.nih.gov/health/health-topics/topics/bdt/types. Last updated 1/6/2012. Accessed November 8, 2015.
NIH. NIH. US National Library of Medicine. Medline Plus: Drug Info: Cimetidine. Available at https://medlineplus.gov/druginfo/meds/a682256.html. Last updated 09/01/2010. Accessed 10/07/2016. 2010.
Nikolich-Zugich J, Messaoudi I. Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Experimental gerontology. Nov 2005;40(11):884-893.
Ning Y, Xu D, Zhang X, et al. beta-glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses. International journal of cancer. Journal international du cancer. Jun 1 2016;138(11):2713-2723.
Nishiguchi S, Tamori A, Shiomi S, et al. Cimetidine reduces impairment of cellular immunity after transcatheter arterial embolization in patients with hepatocellular carcinoma. Hepato-gastroenterology. Mar-Apr 2003;50(50):460-462.
Niu X, Yang Y, Wang J. Synergistic and additive effects of cimetidine and levamisole on cellular immune responses to hepatitis B virus DNA vaccine in mice. Scandinavian journal of immunology. Feb 2013;77(2):84-91.
Noverr MC, Huffnagle GB. Does the microbiota regulate immune responses outside the gut? Trends in microbiology. Dec 2004;12(12):562-568.
O'Sullivan M, McLean-Tooke A, Loh RK. Antinuclear antibody test. Australian family physician. Oct 2013;42(10):718-721.
Oh B, Kim JS, Kweon M, Kim BS, Huh IS. Six-week Diet Correction for Body Weight Reduction and Its Subsequent Changes of Gut Microbiota: A Case Report. Clin Nutr Res. Apr 2016;5(2):137-140.
Oldways. What is the Mediterranean Diet? https://oldwayspt.org/traditional-diets/mediterranean-diet/what-mediterranean-diet. Accessed 8/16/2016.
Oliviero F, Spinella P, Fiocco U, Ramonda R, Sfriso P, Punzi L. How the Mediterranean diet and some of its components modulate inflammatory pathways in arthritis. Swiss medical weekly. 2015;145:w14190.
Palmer DB. The effect of age on thymic function. Frontiers in immunology. 2013;4:316.
Pandey VK, Amin PJ, Shankar BS. G1-4A, a polysaccharide from Tinospora cordifolia induces peroxynitrite dependent killer dendritic cell (KDC) activity against tumor cells. International immunopharmacology. Dec 2014;23(2):480-488.
Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP. Repurposing drugs in oncology (ReDO)-cimetidine as an anti-cancer agent. Ecancermedicalscience. 2014;8:485.
Parkin J, Cohen B. An overview of the immune system. Lancet. Jun 2 2001;357(9270):1777-1789.
Pawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A. Cytomegalovirus and human immunosenescence. Reviews in medical virology. Jan 2009;19(1):47-56.
Pera A, Campos C, Lopez N, Hassouneh F, Alonso C, Tarazona R, Solana R. Immunosenescence: Implications for response to infection and vaccination in older people. Maturitas. Sep 2015;82(1):50-55.
Percival SS. Aged Garlic Extract Modifies Human Immunity. The Journal of nutrition. Feb 2016;146(2):433s-436s.
Perez-Martinez A, Valentin J, Fernandez L, et al. Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo. Cytotherapy. May 2015;17(5):601-612.
Pishel I, Shytikov D, Orlova T, Peregudov A, Artyuhov I, Butenko G. Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis. Rejuvenation Res. Apr 2012;15(2):239-248.
Pohanka M, Pejchal J, Snopkova S, Havlickova K, Karasova JZ, Bostik P, Pikula J. Ascorbic acid: an old player with a broad impact on body physiology including oxidative stress suppression and immunomodulation: a review. Mini reviews in medicinal chemistry. Jan 2012;12(1):35-43.
Polak L. The transfer of tolerance to DNCB-contact sensitivity in guinea pigs by parabiosis. J Immunol. Mar 1975;114(3):988-991.
Prall SP, Muehlenbein MP. Dehydroepiandrosterone and multiple measures of functional immunity in young adults. American journal of human biology: the official journal of the Human Biology Council. Nov-Dec 2015;27(6):877-880.
Prasad AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American journal of clinical nutrition. Mar 2007;85(3):837-844.
Prather AA, Janicki-Deverts D, Hall MH, Cohen S. Behaviorally Assessed Sleep and Susceptibility to the Common Cold. Sleep. 2015;38(9):1353-1359.
Pregliasco F, Anselmi G, Fonte L, Giussani F, Schieppati S, Soletti L. A new chance of preventing winter diseases by the administration of synbiotic formulations. Journal of clinical gastroenterology. Sep 2008;42 Suppl 3 Pt 2:S224-233.
Purev U, Chung MJ, Oh DH. Individual differences on immunostimulatory activity of raw and black garlic extract in human primary immune cells. Immunopharmacology and immunotoxicology. Aug 2012;34(4):651-660.
Purwanto B, Prasetyo DH. Effect of oral N-acetylcysteine treatment on immune system in continuous ambulatory peritoneal dialysis patients. Acta medica Indonesiana. Apr 2012;44(2):140-144.
Quest. Quest Diagnostics. Test Center. C3 and C4 Complement. http://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=65201A &labCode=QER. Accessed November 8, 2015.
Ravussin E, Redman LM, Rochon J, et al. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. Sep 2015;70(9):1097-1104.
Ray B, Hutterer C, Bandyopadhyay SS, et al. Chemically engineered sulfated glucans from rice bran exert strong antiviral activity at the stage of viral entry. Journal of natural products. Dec 27 2013;76(12):2180-2188.
Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, Conboy IM. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nature communications. Nov 22 2016;7:13363.
Rege N, Bapat RD, Koti R, Desai NK, Dahanukar S. Immunotherapy with Tinospora cordifolia: a new lead in the management of obstructive jaundice. Indian journal of gastroenterology: official journal of the Indian Society of Gastroenterology. Jan 1993;12(1):5-8.
Rezzani R, Nardo L, Favero G, Peroni M, Rodella LF. Thymus and aging: morphological, radiological, and functional overview. Age (Dordrecht, Netherlands). Feb 2014;36(1):313-351.
Ried K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. The Journal of nutrition. Feb 2016;146(2):389s-396s.
Rizza W, Veronese N, Fontana L. What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev. Jan 2014;13:38-45.
Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE. A bovine whey protein extract can enhance innate immunity by priming normal human blood neutrophils. The Journal of nutrition. Feb 2009;139(2):386-393.
Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. International journal of immunopathology and pharmacology. Dec 2015;28(4):521-531.
Sansoni P, Vescovini R, Fagnoni FF, et al. New advances in CMV and immunosenescence. Experimental gerontology. Jul 2014;55:54-62.
Santus P, Corsico A, Solidoro P, Braido F, Di Marco F, Scichilone N. Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. COPD. Dec 2014;11(6):705-717.
Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PA. Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell. Jun 2013;12(3):381-387.
Schiaffino S, Pereira MG, Ciciliot S, Rovere-Querini P. Regulatory T cells and skeletal muscle regeneration. The FEBS journal. Aug 1 2016.
Schlick K, Grundbichler M, Auberger J, et al. Cytomegalovirus reactivation and its clinical impact in patients with solid tumors. Infectious agents and cancer. 2015;10:45.
Schmitt V, Rink L, Uciechowski P. The Th17/Treg balance is disturbed during aging. Experimental gerontology. Dec 2013;48(12):1379-1386.
Schröder AK, Rink L. Neutrophil immunity of the elderly. Mechanisms of ageing and development. 2003;124(4):419-425.
Schwingshackl L, Hoffmann G. Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutrition, metabolism, and cardiovascular diseases: NMCD. Sep 2014;24(9):929-939.
Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. bioRxiv. 2016-01-01 00:00:00 2016.
Serrano-Villar S, Sainz T, Lee SA, et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS pathogens. May 2014;10(5):e1004078.
Sha S. Stanford University. The PLasma for Alzheimer SymptoM Amelioration (PLASMA) Study: Intravenously-Administered Plasma From Young Donors for Treatment of Mild-To-Moderate Alzheimer's Disease. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Last updated 2016 Nov. 29. https://clinicaltrials.gov/ct2/show/NCT02256306. NLM Identifier: NCT02256306.
Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. Immunomodulatory active compounds from Tinospora cordifolia. Journal of ethnopharmacology. Jun 14 2012;141(3):918-926.
Sheeja K, Kuttan G. Andrographis paniculata downregulates proinflammatory cytokine production and augments cell mediated immune response in metastatic tumor-bearing mice. Asian Pacific journal of cancer prevention: APJCP. 2010;11(3):723-729.
Shrivastava AK, Singh HV, Raizada A, et al. Inflammatory markers in patients with rheumatoid arthritis. Allergologia et immunopathologia. Jan-Feb 2015;43(1):81-87.
Simoes CD, Maukonen J, Scott KP, Virtanen KA, Pietilainen KH, Saarela M. Impact of a very low-energy diet on the fecal microbiota of obese individuals. Eur J Nutr. Sep 2014;53(6):1421-1429.
Simpson RJ. Aging, persistent viral infections, and immunosenescence: can exercise "make space"? Exercise and sport sciences reviews. Jan 2011;39(1):23-33.
Simpson RJ, Cosgrove C, Chee MM, et al. Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exercise immunology review. 2010;16:40-55.
Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Progress in molecular biology and translational science. 2015;135:355-380.
Siqueiros-Cendon T, Arevalo-Gallegos S, Iglesias-Figueroa BF, Garcia-Montoya IA, Salazar-Martinez J, Rascon-Cruz Q. Immunomodulatory effects of lactoferrin. Acta pharmacologica Sinica. 2014;35(5):557-566.
Smithey MJ, Li G, Venturi V, Davenport MP, Nikolich-Zugich J. Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life. J Immunol. Dec 1 2012;189(11):5356-5366.
Snyder CM, Cho KS, Bonnett EL, Allan JE, Hill AB. Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus. PLoS pathogens. Oct 2011;7(10):e1002295.
Sorice A, Guerriero E, Capone F, Colonna G, Castello G, Costantini S. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini reviews in medicinal chemistry. May 2014;14(5):444-452.
Spiegel K, Sheridan JF, Van Cauter E. Effect of sleep deprivation on response to immunization. JAMA. Sep 25 2002;288(12):1471-1472.
Spielmann G, McFarlin BK, O'Connor DP, Smith PJ, Pircher H, Simpson RJ. Aerobic fitness is associated with lower proportions of senescent blood T-cells in man. Brain Behav Immun. Nov 2011;25(8):1521-1529.
Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis. Nov 1 2006;43(9):1143-1151.
Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L. Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell. Aug 2012;11(4):644-650.
Steven S, Taylor R. Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration Type 2 diabetes. Diabet Med. Sep 2015;32(9):1149-1155.
Storey M, Jordan S. An overview of the immune system. Nursing standard (Royal College of Nursing (Great Britain): 1987). Dec 17-2009 Jan 6 2008;23(15-17):47-56; quiz 58, 60.
Straub RH, Konecna L, Hrach S, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. The Journal of clinical endocrinology and metabolism. Jun 1998;83(6):2012-2017.
Tayama E, Hayashida N, Fukunaga S, Tayama K, Takaseya T, Hiratsuka R, Aoyagi S. High-dose cimetidine reduces proinflammatory reaction after cardiac surgery with cardiopulmonary bypass. The Annals of thoracic surgery. Dec 2001;72(6):1945-1949.
Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, Fukuda K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. Jan 8 2003;289(2):179-186.
Uchio R, Hirose Y, Murosaki S, Yamamoto Y, Ishigami A. High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice. The British journal of nutrition. Feb 28 2015;113(4):603-609.
UMMC. University of Maryland Medical Center. Dehydroepiandrosterone. https://umm.edu/health/medical/altmed/supplement/dehydroepiandrosterone. 6/26/2014. Accessed November 12, 2015.
US Department of Health and Human Services, US Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. 8th ed. Washington, DC: US Dept of Health and Human Services; 2015.
Valenti P, Antonini G. Lactoferrin: an important host defence against microbial and viral attack. Cellular and molecular life sciences: CMLS. Nov 2005;62(22):2576-2587.
Vannucci L, Krizan J, Sima P, et al. Immunostimulatory properties and antitumor activities of glucans (Review). International journal of oncology. Aug 2013;43(2):357-364.
Varadhan R, Yao W, Matteini A, et al. Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2014;69A(2):165-173.
Vazirian M, Faramarzi MA, Ebrahimi SE, et al. Antimicrobial effect of the Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) and its main compounds. International journal of medicinal mushrooms. 2014;16(1):77-84.
Vescovini R, Fagnoni FF, Telera AR, et al. Naive and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus. Age (Dordrecht, Netherlands). Apr 2014;36(2):625-640.
Vickery BP, Scurlock AM, Jones SM, Burks AW. Mechanisms of immune tolerance relevant to food allergy. The Journal of allergy and clinical immunology. Mar 2011;127(3):576-584; quiz 585-576.
Vieira SM, Pagovich OE, Kriegel MA. Diet, microbiota and autoimmune diseases. Lupus. May 2014;23(6):518-526.
Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clinical and experimental immunology. Sep 2008;153 Suppl 1:3-6.
Villeda SA, Luo J, Mosher KI, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. Aug 31 2011;477(7362):90-94.
Villeda SA, Plambeck KE, Middeldorp J, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. Jun 2014;20(6):659-663.
Villeda SA, Wyss-Coray T. The circulatory systemic environment as a modulator of neurogenesis and brain aging. Autoimmunity reviews. Apr 2013;12(6):674-677.
Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Herbal Medicine: Biomolecular and Clinical Aspects, 2nd ed. Chapter 9: Ganoderma lucidum (Lingzhi or Reishi) - A Medicinal Mushroom. Benzie IFF and Wachtel-Galor S, eds. Boca Raton (FL): CRC Press/Taylor & Francis. Copyright 2011. http://www.ncbi.nlm.nih.gov/books/NBK92757/#ch9_sec9. Accessed 4/1/2016.
Wang GC, Kao WH, Murakami P, et al. Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. American journal of epidemiology. May 15 2010;171(10):1144-1152.
Wang J, Su B, Ding Z, Du X, Wang B. Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells. Biochemical and biophysical research communications. Aug 1 2008;372(3):491-496.
Wang R, Jaw JJ, Stutzman NC, Zou Z, Sun PD. Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1. Journal of leukocyte biology. Feb 2012;91(2):299-309.
Waterhouse NJ, Sutton VR, Sedelies KA, et al. Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. The Journal of cell biology. Apr 10 2006;173(1):133-144.
Weiskopf D, Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl Int. Nov 2009;22(11):1041-1050.
Weksler ME. Immune senescence and adrenal steroids: immune dysregulation and the action of dehydroepiandrosterone (DHEA) in old animals. Eur J Clin Pharmacol. 1993;45 Suppl 1:S21-23; discussion S43-24.
Wilder-Smith A, Mustafa FB, Earnest A, Gen L, Macary PA. Impact of partial sleep deprivation on immune markers. Sleep medicine. Oct 2013;14(10):1031-1034.
Witek-Janusek L, Albuquerque K, Chroniak KR, Chroniak C, Durazo-Arvizu R, Mathews HL. Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain Behav Immun. Aug 2008;22(6):969-981.
Wolach B, van der Laan LJ, Maianski NA, Tool AT, van Bruggen R, Roos D, Kuijpers TW. Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro. Experimental hematology. Apr 2007;35(4):541-550.
Woods JA, Keylock KT, Lowder T, et al. Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial. J Am Geriatr Soc. Dec 2009;57(12):2183-2191.
Wu D, Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol. Oct 2008;84(4):900-914.
Wu D, Meydani SN. Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets. 2014;14(4):283-289.
Wu Z, Zhang Y, Tan N, Zhao C, Yang J, Zhu J-S. ReishiMax extends the lifespan of mice: A preliminary report. The FASEB Journal. 2011;25(1 Supplement):601.602.
Xu Y, Chen A, Fry S, Barrow RA, Marshall RL, Mukkur TK. Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide. International immunopharmacology. Apr 2007;7(4):515-523.
Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. The American journal of Chinese medicine. 2011;39(1):15-27.
Yan F, Polk DB. Probiotics and immune health. Current opinion in gastroenterology. Oct 2011;27(6):496-501.
Yang H, Youm YH, Dixit VD. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol. Sep 1 2009;183(5):3040-3052.
Yonei Y, Kitano T, Ogura M, et al. Effects of health food containing Cistanche deserticola extract on qol and safety in elderly: an open pilot study of 12-week oral treatment. Anti-Aging Medicine. 2011;8(2):7-14.
Yu HT, Shin EC. T cell immunosenescence, hypertension, and arterial stiffness. Epidemiology and health. 2014;36:e2014005.
Zagulski T, Lipinski P, Zagulska A, Broniek S, Jarzabek Z. Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. British journal of experimental pathology. Dec 1989;70(6):697-704.
Zakharova ET, Kostevich VA, Sokolov AV, Vasilyev VB. Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha. Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine. Dec 2012;25(6):1247-1259.
Zhai Z, Liu Y, Wu L, et al. Enhancement of innate and adaptive immune functions by multiple Echinacea species. Journal of medicinal food. Sep 2007;10(3):423-434.
Zhang C, Li S, Yang L, et al. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nature communications. 2013;4.
Zhang H, Puleston DJ, Simon AK. Autophagy and Immune Senescence. Trends in molecular medicine. Aug 2016;22(8):671-686.
Zhang K, Ma X, He W, et al. Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice. Evidence-based complementary and alternative medicine: eCAM. 2014;2014:601383.
Zhang L, Shao WF, Yuan LF, Tu PF, Ma ZZ. Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM). Food chemistry. Dec 15 2012;135(4):2222-2228.
Zhang W, Wang J, Su B, Li R, Ding Z, Kang Y, Wang B. Cimetidine augments Th1/Th2 dual polarized immune responses to recombinant HBV antigens. Vaccine. Jun 24 2011;29(29-30):4862-4868.
Zhao X, Qian Y, Zhou YL, Wang R, Wang Q, Li GJ. Pu-erh tea has in vitro anticancer activity in TCA8113 cells and preventive effects on buccal mucosa cancer in U14 cells injected mice in vivo. Nutr Cancer. 2014;66(6):1059-1069.
Zheng Q, Cui G, Chen J, et al. Regular Exercise Enhances the Immune Response Against Microbial Antigens Through Up-Regulation of Toll-like Receptor Signaling Pathways. Cell Physiol Biochem. 2015;37(2):735-746.
Zuppa C, Prado CH, Wieck A, Zaparte A, Barbosa A, Bauer ME. Acupuncture for sleep quality, BDNF levels and immunosenescence: a randomized controlled study. Neuroscience letters. Feb 5 2015;587:35-40.