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The Unscientific Bioidentical Hormone Debate

October 2009

By William Faloon

Oprah Winfrey Criticized for Airing Scientific Truths

Oprah Winfrey Criticized for Airing Scientific Truths

On January 29, 2009, Oprah Winfrey dedicated an entire one-hour program to the bioidentical hormone debate. Oprah did her research and identified numerous maturing women who suffered horrendous quality-of-life deficits that were reversed by bioidentical hormones.

Oprah assigned one of the most prestigious medical doctors in the United States (Dr. Mehmet Oz) to go inside a compounding pharmacy to show the audience how much quality control goes into making a compounded natural hormone cream.

Suzanne Somers was the featured guest, along with doctors who urged aging women to have their blood tested and their hormones naturally restored.

In her O magazine, Oprah Winfrey stated: “After one day on bioidentical estrogen, I felt the veil lift. After three days, the sky was bluer, my brain was no longer fuzzy, my memory was sharper. I was literally singing and had a skip in my step.”9

Unfortunately, Oprah Winfrey tried to air a “balanced” report on her TV show, in which the opposition got to torpedo scientific reality with sound bite scare tactics that have no basis in fact. Oprah found mainstream doctors who supported the FDA’s biased position against bioidentical hormones. These doctors attacked the safety of bioidentical hormones and suggested that aging women should do virtually nothing to restore youthful hormone balance, or rely only on FDA-approved hormone drugs.

After the program, some media sources were critical that Oprah favored the bioidentical side of the debate, and claimed that Oprah was “damaging” women’s health by suggesting women could benefit from bioidentical hormones.

News Media Disseminates Blatantly False Information

Drug companies appear to be terrified of Oprah Winfrey. Many months after Oprah’s bioidentical hormone show aired, the news media was still finding doctors to criticize her. Drug companies spend huge amounts of money on public relations firms for the purpose of influencing the public, as well as the FDA and Congress.

One prominent news magazine quoted a doctor as stating:

“Despite (Suzanne) Somers’s claim that her specially made, non-FDA-approved bioidenticals are “natural” and safer, they are actually synthetic, just like conventional hormones and FDA-approved bioidenticals from pharmacies—and there are no conclusive clinical studies showing they are less risky.”10

As you will read in the White Paper on Bioidentical Hormones appearing in this month’s issue, numerous clinical studies substantiate the safety and efficacy of these “natural to the human body” hormones3 extolled by Oprah Winfrey, Suzanne Somers, and tens of thousands of anti-aging doctors and their patients.

Most appalling are the innuendos that bioidentical hormones are no different than FDA-approved Premarin® and Prempro®. Both Premarin® and Prempro® contain horse estrogen extracted from pregnant mares’ urine. Unlike bioidentical estrogen creams that provide the hormones found naturally in the human female body, horse estrogen contains equilin and other equine estrogens found exclusively in horses!11,12

The human female body contains enzymes to metabolize the natural proportion of estriol, estradiol, and estrone, but not horse estrogens such as equilin. These horse estrogens produce estrogenic effects that are much more potent and longer-lasting than those produced by natural human estrogens.13

As two leading reproductive physiologists point out, when women take Premarin®:

“Levels [of equilin] can remain elevated for 13 weeks or more post-treatment due to storage and slow release from adipose [fat] tissue. In addition, metabolism of equilin to equilenin and 17-hydroxyequilenin may contribute to the estrogen stimulatory effect of [conjugated estrogen] therapy.”14

Another metabolite of equilin, 17-dihydroequilin has been found to be eight times more potent than equilin for inducing endometrial growth, a possible precursor to cancer.14

The drug Prempro® consists of conjugated equine estrogens and medroxyprogesterone acetate, a synthetic progestin that has been implicated in many of the adverse effects uncovered in the Women’s Health Initiative study.4 Medroxyprogesterone acetate is not the same as natural progesterone found in bioidentical hormone creams, yet establishment doctors are telling the news media that there is no difference.

There are other FDA-approved estrogen drugs that provide too much estrone and estradiol (and no estriol). These so-called “natural estrogen” drugs are also not the same as bioidentical hormone creams that can be obtained from compounding pharmacies.15

On the January 29th 2009 show, Oprah Winfrey warned the medical establishment: “We have the right to demand a better quality of life for ourselves, and that’s what doctors have got to learn to start respecting.”10

Profit-driven pharmaceutical companies don’t want patients to revolt and seem willing to disseminate egregiously falsified propaganda to protect their multi-billion dollar assembly line franchise of dangerous estrogen/synthetic progestin drugs.

Follow the Money and Ye Shall Find the Truth

The Oprah Winfrey Show strongly supported the anti-aging benefits women could attain from bioidentical hormones. Regrettably, the conventional doctors Oprah used to “balance” the program served their purpose, i.e., they cast doubt on the safety of natural hormones. These sound-bite scare tactics (often used by those running for political office), will cause most aging women to do nothing to restore their hormones based on imaginary fears.

The fully referenced White Paper on Bioidentical Hormones that appears in this month’s issue provides irrefutable scientific evidence, but perhaps a simpler method to discern the truth is to see who economically benefits from the hormone debate.

Pharmaceutical companies lavish conventional doctors with enormous financial rewards in exchange for these doctors’ support of FDA-approved drugs. The economic incentive for mainstream doctors is thus to toe the pharmaceutical industry’s party line and attack those who offer natural alternatives.

But what are the financial motivations of Oprah Winfrey, Suzanne Somers, and the numerous beneficiaries of bioidentical hormones that appeared on Oprah’s show? The fact is that NONE of them sells bioidentical hormones. They represent the uncompensated majority who only seeks out the truth, without money influencing their decision-making process.

As I stated earlier in this article, the Life Extension Pharmacy™ does not sell estriol-based natural estrogen creams because of the FDA’s ban. I am, however, standing behind the hard science in recommending that women who choose to use estrogen drugs obtain them from compounding pharmacies that are small enough to avoid the FDA’s draconian ban against estriol.

When listening to future debates about whether women should use FDA-approved hormone drugs that are proven to kill, as opposed to bioidentical hormones whose safety and efficacy are strongly supported, follow the money and you will see who has your best interests at heart.

Using Hard Science to Silence Our Critics

An entire book could be written about the absurd lies promulgated by pharmaceutical company-funded doctors who seek to frighten aging women away from natural hormones. In a recent national news magazine, for instance, a board-certified endocrinologist was quoted, “There is no medical reason to use progesterone after a hysterectomy.”16 When one considers the multitude of essential bodily functions dependent on progesterone, you have to wonder what board certifies these “endocrinologists” for competence.

The in-depth report in this month’s issue presents irrefutable scientific evidence in support of the safety-efficacy of estriol and natural progesterone. This Bioidentical Hormone White Paper may forever silence our uninformed and/or corrupted critics, at least in the minds of those fortunate enough to read it.

It is the masses who are victimized by self-serving pharmaceutical company propaganda and FDA edicts (such as banning estriol). They suffer either the agonies of lifelong hormone deprivation—or the lethal effects of chronic exposure to dangerous forms of hormone drugs.

I am proud to be able to pub-lish the article in this month’s issue that provides lifesaving scientific facts that are not tainted by financial bias.

For longer life,

For Longer Life

William Faloon

Pharmaceutical Company Pays Ghostwriters To Push Dangerous Hormone Drugs

Drug company Wyeth faces 8,400 lawsuits from women who claim Premarin® or PremPro® caused them to become ill.

Newly released court documents from these cases reveal that Wyeth paid ghostwriters to produce 26 “scientific” papers supporting the use of their dangerous hormone drugs.

The Wyeth-funded articles extolled purported benefits of these unnatural hormone drugs while downplaying their lethal risks. Nowhere in these articles was Wyeth’s role in initiating and paying for them disclosed.

Court documents show how Wyeth contracted with private companies to outline articles, draft them and then solicit top physicians to sign their names, even though many of the doctors contributed little or no writing to them.

Physician prescribing practices are strongly influenced by what they read in peer-reviewed scientific publications. These tainted articles were published in medical journals between 1998 and 2005, and helped generate billions of dollars of sales for Wyeth.

These revelations substantiate allegations that Life Extension® made decades ago that drug companies manipulate scientific data to enable dangerous drugs to be prescribed.

Bioidentical Hormones: Why Are They Still Controversial?




3. Postgrad Med. 2009 Jan;121(1):73-85.

4. JAMA. 2002 Jul 17;288(3):321-33.

5. JAMA. 2004 Apr 14;291(14):1701-12.



8. Am J Med. 2009 Jun 4.



11. Br J Clin Pharmacol. 2000 May;49(5):489-90.

12. J Am Soc Mass Spectrom. 2005 Feb;16(2):271-9.

13. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):473-82.

14. Barnes R, Lobo R. Pharmacology of Estrogens. In: Mishell D, ed. Menopause: Physiology and Pharmacology. Chicago, IL: Year Book Medical Publishers, Inc; 1986.