Daily News

Daily News

Lean body mass increased in response to dietary vitamin D administration in experimental research

Health & Medicine Daily

2019 NOV 07 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New research on Health and Medicine - Diet and Nutrition is the subject of a report. According to news reporting originating from Quebec, Canada, by NewsRx correspondents, research stated, “Vitamin D status positively relates to lean body mass in infants. This study tested the effect of vitamin D on body composition and growth-related hormones.”

Financial supporters for this research include Dairy Farmers of Canada, Natural Sciences and Engineering Research Council of Canada, Canada Foundation for Innovation.

Our news editors obtained a quote from the research from McGill University, “It was hypothesized that low vitamin D status programs for higher fat mass accretion. Female weanling Sprague-Dawley rats (4 weeks; n=6/diet) were randomized to AIN-93G diets with modified vitamin D contents for 8 weeks: group 1 (1 IU vitamin D/g diet), group 2 (2 IU vitamin D/g diet), and group 3 (4 IU vitamin D/g diet). At week 0, 4, and 8 of study, measurements included: serum 25(OH)D, IGF-1, IGFBP3, leptin, and whole body composition assessed with DXA. Differences among groups were tested using mixed model ANOVA with Tukey’s post hoc t-tests. No differences were observed in baseline body composition and biomarkers, nor did body weight and food intake differ over the study. At week 8, serum 25(OH)D in group 3 was higher (p <.0001) compared to groups 1 and 2. At 8 weeks, lean mass (p <.05) and lean mass accretion (p <.05) were significantly higher in groups 2 and 3 compared to group 1. Serum IGF-1 concentration declined over time (p <.001) with smaller declines at week 8 in group 3 (p <.05). Serum IGFBP3 concentration was lower at week 4 in group 2 compared to groups 1 and 3. Serum leptin concentration and fat mass were not affected by diet.”

According to the news editors, the research concluded: “These results suggested that the achievement of higher vitamin D status may support a lean body phenotype without altering weight gain.”

For more information on this research see: Lean body mass accretion is elevated in response to dietary vitamin D: A dose-response study in female weanling rats. Nutrition Research, 2019;68():92-100. Nutrition Research can be contacted at: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Nutrition Research - http://www.journals.elsevier.com/nutrition-research/)

The news editors report that additional information may be obtained by contacting H.A. Weiler, School of Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Quebec, Canada, H9X 3V9. Additional authors for this research include M. Djekic-Ivankovic, S. Agellon, I. Mak, P. Lavery and H.A Weiler.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.nutres.2019.07.004. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Nutrition Research is: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.

(Our reports deliver fact-based news of research and discoveries from around the world.)