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Protective effect of vitamin D against mandibular osteoporosis induced by corticosteroids and gamma radiation

Health & Medicine Daily

2020 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New research on Musculoskeletal Diseases and Conditions - Osteoporosis is the subject of a report. According to news reporting originating in Cairo, Egypt, by NewsRx journalists, research stated, “Osteoporosis is a progressive systematic skeletal illness characterized by low bone mineral density (BMD), deterioration of microarchitecture of bone tissues and susceptibility to fracture caused by bone resorption. The study investigates the possible role of Alfacalcidol; vitamin D (Vit D) to mitigate osteoporosis induced by corticosteroid and gamma-rays in rats.”

The news reporters obtained a quote from the research from Egyptian Atomic Energy Authority, “Eighty Sprague-Dawley rats were divided equally into eight groups: Control group (1 ml olive oil orally), Epirelefan group (7mg/kg sc), Vit D group (20,000 IU/kg orally), Vit D plus Epirelefan group, Vit D plus gamma-rays (8 Gy) group, Epirelefan plus gamma-rays group, Vit D plus Epirelefan plus gamma-rays group and gamma-rays groups. In Epirelefan group, mandible bone has small cavities, micro fissures, thinning and decrease in the number of trabecular, which may appear rod-like and concave beside increase marrow cavities. In Epirelefan + gamma-rays group, the lesions were more severe with increasing osteoclast and alteration of serum calcium, phosphate and alkaline phosphatase. The administration of Vit D before corticosteroid injection and pre gamma-rays-irradiation has significantly reduced mandibular damage.”

According to the news reporters, the research concluded: “Vit D could be efficient in mitigating osteoporosis occurred by corticosteroid and gamma-rays in rat model.”

For more information on this research see: Protective Effect of Vitamin D Against Rats’ Mandibular Osteoporosis Induced By Corticosteroids and Gamma Rays. Internatuinal Journal of Radiation Research, 2020;18(1):125-131. Internatuinal Journal of Radiation Research can be contacted at: Ijrr-Iranian Journal Radiation Res, No 29, 4TH Fl, Chamran Medical Bldg, Parvaneh St, Ale-Ahmad Hwy, Tehran, 00000, Iran.

Our news correspondents report that additional information may be obtained by contacting A.A. Elkady, Ncrrt, Egyptian Atomic Energy Authority, Health Radiation Research Department, 29 Nasr City, Cairo, Egypt. Additional authors for this research include H.H. Kazem and E.A. Elgendy.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.18869/acadpub.ijrr.18.1.125. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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