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Research suggests soy metabolite could have neuroprotective effects

Taiwan Daily Report

2020 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- A new study on Proteins - Estrogen Receptors is now available. According to news reporting from Taoyuan, Taiwan, by NewsRx journalists, research stated, “Beta-amyloid formation in the brain is one of the characteristics of Alzheimer’s disease. Exposure to this peptide may result in reentry into the cell cycle leading to cell death.”

Financial support for this research came from Research Program of Taoyuan General Hospital, Taiwan.

The news correspondents obtained a quote from the research from Kainan University, “The phytoestrogen equol has similar biological effects as estrogen without the side effects. This study investigated the possible mechanism of the neuron cell-protecting effect of equol during treatment with A beta. SH-SY5Y neuroblastoma cells were treated with either 1 mu M S-equol or 10 nM 17 beta-estradiol for 24 h prior to 1 mu M A beta (25-35) exposure. After 24 h exposure to A beta (25-35), a significant reduction in cell survival and a reentry into the cell cycle process accompanied by increased levels of cyclin D1 were observed. The expressions of estrogen receptor alpha (ER alpha) and its coactivator, steroid receptor coactivator-1 (SRC-1), were also significantly downregulated by A beta (25-35) in parallel with activated extracellular signal-regulated kinase (ERK)1/2. However, pretreatment of cells with S-equol or 17 beta-estradiol reversed these effects. Treatment with the ER antagonist, ICI-182,780 (1 mu M), completely blocked the effects of S-equol and 17 beta-estradiol on cell viability, ER alpha, and ERK1/2 after A beta (25-35) exposure. These data suggest that S-equol possesses a neuroprotective potential as it effectively antagonizes A beta (25-35)-induced cell cytotoxicity and prevents cell cycle reentry in SH-SY5Y cells.”

According to the news reporters, the research concluded: “The mechanism underlying S-equol neuroprotection might involve ER alpha-mediated pathways.”

For more information on this research see: Equol Pretreatment Protection of SH-SY5Y Cells against Ab (25-35)-Induced Cytotoxicity and Cell-Cycle Reentry via Sustaining Estrogen Receptor Alpha Expression. Nutrients, 2019;11(10):2356. Nutrients can be contacted at: Mdpi, St Alban-Anlage 66, Ch-4052 Basel, Switzerland.

Our news journalists report that additional information may be obtained by contacting C.I. Lin, Kainan University, Dept. of Nutrition and Health Sciences, Taoyuan 33857, Taiwan. Additional authors for this research include M.C. Tsai, S.H. Lin and K. Hidayah.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3390/nu11102356. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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