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Rate of brain aging and APOE e4 are synergistic risk factors for Alzheimer disease

Pain & Central Nervous System Daily News

2020 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Data detailed on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been presented. According to news originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, “Advanced age and the APOE epsilon 4 allele are the two biggest risk factors for Alzheimer’s disease (AD) and declining cognitive function. We describe a universal gauge to measure molecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25-97) free of neurological disease.”

Funders for this research include Glenn Foundation for Medical Research, American Federation for Aging Research.

Our news journalists obtained a quote from the research from the Massachusetts Institute of Technology, “In a fifth cohort of older subjects with or without neurological disease (n = 438, ages 67-108), we show that subjects with brains deviating in the older direction from what would be expected based on chronological age show an increase in AD, Parkinson’s disease, and cognitive decline. Strikingly, a younger molecular age (-5 yr than chronological age) protects against AD even in the presence of APOE epsilon 4. An established DNA methylation gauge for age correlates well with the transcriptome gauge for determination of molecular age and assigning deviations from the expected.”

According to the news editors, the research concluded: “Our results suggest that rapid brain aging and APOE epsilon 4 are synergistic risk factors, and interventions that slow aging may substantially reduce risk of neurological disease and decline even in the presence of APOE epsilon 4.”

For more information on this research see: Rate of brain aging and APOE e4 are synergistic risk factors for Alzheimer’s disease. Life Science Alliance, 2019;2(3):e201900303. Life Science Alliance can be contacted at: Life Science Alliance Llc, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA.

The news correspondents report that additional information may be obtained from C.A. Glorioso, Massachusetts Institute of Technology, Dept. of Biology, 77 Massachusetts Ave, Cambridge, MA 02139, United States. Additional authors for this research include S.S. Lee, L.P. Guarente, A.R. Pfenning, D.A. Bennett, E.L. Sibille and M. Kellis.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.26508/lsa.201900303. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)