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Resveratrol promotes new bone formation via activating SIRT1/FoxO1 pathway in mouse model of osteoporosis

Health & Medicine Daily

2020 FEB 25 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Researchers detail new data in Musculoskeletal Diseases and Conditions - Osteoporosis. According to news reporting originating in Chengdu, People’s Republic of China, by NewsRx journalists, research stated, “This study aimed to investigate the effects of resveratrol (3, 4’, 5-trihydroxystilbene, RES) on osteoporosis and the role of SIRT1/FoxO1 pathway in the process. In vivo, mice were divided into 3 groups, Sham, ovariectomized (OVX) and OVX-RES group.”

Financial supporters for this research include China Postdoctoral Science Foundation, West China Hospital, Sichuan University.

The news reporters obtained a quote from the research from Sichuan University, “Micro-CT, histology and histomorphometry were conducted to detect details of bone mass and microstructure. The expression of osteoblast markers was tested by Real-time qPCR and serum markers which reflected bone formation and resorption were analyzed by enzyme-linked immunosorbent assay (ELISA). Besides, we assayed sirtuin 1 (SIRT1) expression and the concentration of serum superoxide dismutase (SOD). In vitro, osteoblasts were seperated into 3 groups: control, HO (hydrogen peroxide, HO) and HO-RES group. Cell proliferation, differentiation and apoptosis were detected. In addition, we tested intracellular reactive oxygen species (ROS) formation and SOD activity detection of osteoblasts. The SIRT1, acetylated FoxO1 (Ac-FoxO1) and nuclear FoxO1 (Nu-FoxO1) expression were detected by Western blot. Results revealed that RES could ameliorate bone loss and promote osteogenesis by reinforcing resistance of oxidative stress in OVX mice. RES enhanced proliferation, differentiation and suppressed apoptosis of HO-treated osteoblasts. In this process, SIRT1 was upregulated and the level of Nu-FoxO1, which had high transcriptional activity to regulate redox balance, significantly increased. Oxidative stress plays a crucial role in osteoporosis.”

According to the news reporters, the research concluded: “RES can reinforce resistance to oxidative damage and hence promote osteogenesis via the activation of SIRT1/FoxO1 signaling pathway, which provides a new idea for the prevention and treatment of osteoporosis.”

For more information on this research see: Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice. Life Sciences, 2020;246():117422. Life Sciences can be contacted at: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Life Sciences - http://www.journals.elsevier.com/life-sciences/)

Our news correspondents report that additional information may be obtained by contacting X. Wang, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People’s Republic of China. Additional authors for this research include Y. Jiang, W. Luo, B. Wang, P. Gong and Y. Xiong.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.lfs.2020.117422. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the journal Life Sciences can be contacted at: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.

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