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Cancer and Alzheimer disease share common risk factors

Cancer Daily

2020 JUL 09 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- New research on Neurodegenerative Diseases and Conditions - Alzheimer Disease is the subject of a report. According to news reporting out of Orsay, France, by NewsRx editors, research stated, “Alzheimer’s disease (AD) and cancer have much in common than previously recognized. These pathologies share common risk factors (inflammation and aging), with similar epidemiological and biochemical features such as impaired mitochondria.”

Our news journalists obtained a quote from the research from the University of Paris Sud, “Metabolic reprogramming occurs during aging and inflammation. We assume that inflammation is directly responsible of the Warburg effect in cancer cells, with a decreased oxidative phosphorylation and a compensatory highthroughput glycolysis (HTG). Similarly, the Warburg effect in cancer is thought to support an alkaline intracellular pH (pHi), a key component of unrelenting cell growth. In the brain, inflammation results in increased secretion of lactate by astrocytes. The increased uptake of lactic acid by neurons results in the inverse Warburg effect, such as seen in AD. The neuronal activity is dampened by a fall of pHi. Pronounced cytosol acidification results in decreased mitochondrial energy yield as well as apoptotic cell death. The link between AD and cancer is reinforced by the fact that treatment aiming at restoring the mitochondrial activity have been experimentally shown to be effective in both diseases.”

According to the news editors, the research concluded: “Low carb diet, lipoic acid, and/or methylene blue could then appear promising in both sets of these clinically diverse diseases.”

For more information on this research see: Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders. Biogerontology, 2020;():. Biogerontology can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Biogerontology - http://www.springerlink.com/content/1389-5729/)

Our news journalists report that additional information may be obtained by contacting Sabine Peres, LRI, University of Paris Sud, National Center for Scientific Research (CNRS), University of Paris Saclay, 91405, Orsay, France. Additional authors for this research include Laurent Schwartz, Mario Jolicoeur and Jorgelindo da Veiga Moreira.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10522-020-09888-6. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Biogerontology is: Springer, 233 Spring Street, New York, NY 10013, USA.

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