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Study finds NT-proBNP best marker of biologic age in older men and women

Clinical Trials Daily

2020 AUG 26 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Daily -- Current study results on Peptide Proteins - Peptide Hormones have been published. According to news reporting out of Bologna, Italy, by NewsRx editors, research stated, “NT-proB-type natriuretic peptide (NT-proBNP) increases with age and is associated with all-cause mortality. With this study, we assessed its possible utilization as a marker of biological age in comparison with other variables.”

Funders for this research include Fondazione Cassa di Risparmio in Bologna, Regione Emilia-Romagna.

Our news journalists obtained a quote from the research from the University of Bologna, “The study included 1079 non-institutionalized elderly subjects (mean age 72.8 ? 5.5 years, 561 women). Baseline measurements were performed of serum NT-proBNP and of some laboratory variables previously utilized to estimate biological age (creatinine, albumin, C-reactive protein, cholesterol, blood glucose, leukocytes, lymphocytes, hemoglobin, mean cell volume). During 7 years of follow-up, 114 all-cause deaths occurred. The logarithm of NT-proBNP was the most age-related parameter (r=0.35, p<0.0001). Its relationship with mortality, according to Cox regression and ROC curve (AUC=0.707, 95% CI 0.654-0.759), was stronger than that of all other variables, including age. In multivariate analysis, only NT-proBNP and age remained independently associated with mortality. The regression lines between age and NT-proBNP (pg/ml) allowed a separate estimation of biological age (‘proBNPage’) for men (=[log(NT-proBNP) + 1.2068]/0.0827) and for women (=[log(NT-proBNP) -1.5258]/0.0478). The hazard ratio of all-cause mortality for the fifth quintile of proBNP age (85 years) compared with the first quintile (<61 years) was 7.9 (95% CI 3.6-17.5). Similarly, the difference between pro-BNPage and chronological age was associated with a hazard ratio of 3.5 in the fifth quintile (95% CI 1.9-6.4) and was associated with disease count (P for trend=0.0002).”

According to the news editors, the research concluded: “NT-proBNP was the best indicator of biological age, which can be estimated by simple formulas and might be used for prognostic purposes or as a surrogate end point in epidemiological and intervention studies.”

For more information on this research see: N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people. Geroscience, 2020;():.

Our news journalists report that additional information may be obtained by contacting Giampaolo Bianchi, Dept. of Medical and Surgical Sciences, University of Bologna S.Orsola-Malpighi Hospital, Via Albertoni, 15, 40138, Bologna, Italy. Additional authors for this research include Antonio Muscari, Paola Forti, Donatella Magalotti, Paolo Pandolfi and Marco Zoli.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s11357-020-00249-2. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)