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Association between number of medications and mortality in geriatric inpatients

Hospital & Nursing Home Daily

2020 SEP 23 (NewsRx) -- By a News Reporter-Staff News Editor at Hospital & Nursing Home Daily -- Data detailed on Aging Research - Geriatrics and Gerontology have been presented. According to news originating from Svendborg, Denmark, by NewsRx correspondents, research stated, “To explore the association between the number of medications and mortality in geriatric inpatients taking activities of daily living and comorbidities into account. A nationwide population-based cohort study was performed including all patients aged 65 years admitted to geriatric departments in Denmark during 2005-2014.”

Financial support for this research came from Lundbeckfonden and Novo Nordisk Fonden.

Our news journalists obtained a quote from the research from Odense University Hospital, “The outcome of interest was mortality. Activities of daily living using Barthel Index (BI) were measured at admission. National health registers were used to link data on an individual level extracting data on medications, and hospital diseases. Patients were followed to the end of study (31/12/2015), death, or emigration, which ever occurred first. Kaplan-Meier survival curves were used to estimate crude survival proportions. Univariable and multivariable analyses were performed using Cox regression. The multivariable analysis were adjusted for age, marital status, period of hospital admission, BMI, and BI (model 1), and additionally either number of diseases (model 2) or Charlson comorbidity index (model 3). We included 74,603 patients (62.8% women), with a median age of 83 (interquartile range [IQR] 77-88) years. Patients used a median of 6 (IQR 4-9) medications. Increasing number of medications was associated with increased overall, 30-day, and 1-year mortality in all three multivariable models for both men and women. For each extra medication, the mortality increased by 3% in women and 4% in men in the fully adjusted model. Increasing number of medications was associated with mortality in this nationwide cohort of geriatric inpatients.”

According to the news editors, the research concluded: “Our findings highlight the importance of polypharmacy in older patients with comorbidities.”

For more information on this research see: Association between number of medications and mortality in geriatric inpatients: a Danish nationwide register-based cohort study. European Geriatric Medicine, 2020;():. (Elsevier - www.elsevier.com; European Geriatric Medicine - http://www.journals.elsevier.com/european-geriatric-medicine/)

The news correspondents report that additional information may be obtained from Kristoffer Kittelmann Brockhattingen, Dept. of Geriatrics, Odense University Hospital, Svendborg Hospital, Baagoes Alle 31, 5700, Svendborg, Denmark. Additional authors for this research include Pavithra Laxsen Anru, Tahir Masud, Mirko Petrovic and Jesper Ryg.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s41999-020-00390-3. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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