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Possible neuroprotective effect of silymarin against aluminum chloride-prompted Alzheimer-like disease in rats

Health & Medicine Daily

2020 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Researchers detail new data in Alzheimer disease. According to news reporting originating from Cairo, Egypt, by NewsRx correspondents, research stated, “Alzheimer’s disease (AD) is a worldwide rapidly growing neurodegenerative disease. Here, we elucidated the neuroprotective effects of silymarin (SM) on the hippocampal tissues of aluminum chloride (AlCl [ [3] ] )-induced Alzheimer-like disease in rats using biochemical, histological, and ultrastructural approaches.”

Our news correspondents obtained a quote from the research from Ain Shams University: “Forty rats were divided into control, SM, AlCl [ [3] ] , and AlCl [ [3] ] + SM groups. Biochemically, AlCl [ [3] ] administration resulted in marked elevation in levels of lipid peroxidation (LPO) and nitric oxide (NO) and decrease in levels of reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Moreover, AlCl [ [3] ] significantly increased tumor necrosis factor-a (TNF-a), interleukin-1beta (IL-1b), and acetylcholinesterase (AChE) activities. Furthermore, myriad histological and ultrastructural alterations were recorded in the hippocampal tissues of AlCl [ [3] ] -treated rats represented as marked degenerative changes of pyramidal neurons, astrocytes, and oligodendrocytes. Additionally, some myelinated nerve fibers exhibited irregular arrangement of their myelin coats, while the others revealed focal degranulation of their myelin sheaths. Severe defects in the blood-brain barrier (BBB) were also recorded.”

According to the news reporters, the research concluded: “However, co-administration of SM with AlCl [ [3] ] reversed most of the biochemical, histological, and ultrastructural changes triggered by AlCl [ [3] ] in rats. The results of the current study indicate that SM can potentially mend most of the previously evoked neuronal damage in the hippocampal tissues of AlCl [ [3] ] -kindled rats.”

For more information on this research see: The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats. Brain Sciences, 2020,10(628):628. (Brain Sciences - http://www.mdpi.com/journal/brainsci/). The publisher for Brain Sciences is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/brainsci10090628.

Our news editors report that more information may be obtained by contacting Hanaa R. Aboelwafa, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo 11566, Egypt. Additional authors for this research include Attalla F. El-kott, Eman M. Abd-Ella, Hany N. Yousef.

(Our reports deliver fact-based news of research and discoveries from around the world.)