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Modulatory effect of methylsulfonylmethane (MSM) against BPA/g-radiation induced neurodegenerative alterations in rats

Health & Medicine Daily

2020 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New research on Diagnostics and Screening - Biomarkers is the subject of a report. According to news reporting out of Cairo, Egypt, by NewsRx editors, research stated, “Methylsulfonylmethane (MSM), is an organosulfur compound, has many health benefits. Bisphenol-A (BPA) and g-radiation ® are two risky environmental contaminants that human beings are exposed to in everyday life.”

Our news journalists obtained a quote from the research from National Centre for Radiation Research and Technology (NCRRT), “This work aims at unveiling the modulatory role of MSM in combating BPA and R co-exposure induced neurodegenerative disorder (Alzheimer’s (AD)-mimic neurotoxicity). Female rats were randomly divided into five groups. One group was normal control and the other four groups were subjected to subacute BPA intoxication and/or exposed to fractionated weekly doses of R for 4 weeks and either untreated or treated with MSM concomitantly. BPA and R co-exposure induced typical hallmarks of neurodegenerative disorders as revealed by tremendously elevated oxidative stress, extensive neuroinflammation (tumor necrosis factor -a and interleukin-1b), elevated AD markers (amyloid-beta (Ab), acetylcholinesterase (AchE) activity and tau-phosphorylation) in cortex and hippocampus as well as up-regulation of microglial pro-inflammatory triggering receptor expressed on myeloid cell-2(TREM-2)/DNAX-activating protein of 12 kDa (DAP-12)/spleen-tyrosine kinase (Syk) pathway and its downstream targets (PLC-g/DAG/p38-MAPK) in hippocampus. Also, neurodegenerative lesions were revealed in histopathological examination of cortex and hippocampus coupled with marked Ab deposition in hippocampus. Whereas, MSM treatment improved histopathological insults and ameliorated level of oxidative stress, neuroinflammation and AD markers as well as modulated TREM-2/DAP-12/Syk pathway.”

According to the news editors, the research concluded: “Our data suggest that MSM afforded neuroprotection against BPA and R; supporting its potential application in the associated neurodegenerative disorders.”

For more information on this research see: Modulatory effect of methylsulfonylmethane against BPA/g-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway. Life Sciences, 2020;260():118410. Life Sciences can be contacted at: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Life Sciences - http://www.journals.elsevier.com/life-sciences/)

Our news journalists report that additional information may be obtained by contacting Mohamed K. Abdel-Rafei, Radiation Biology Division, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.lfs.2020.118410. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Life Sciences is: Pergamon-Elsevier Science LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.

(Our reports deliver fact-based news of research and discoveries from around the world.)