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Melatonin helps prevent Tau aggregation in vitro, suggesting potential use against Alzheimer disease

NewsRx Life Science Daily

2020 MAY 11 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Fresh data on Microtubule Proteins - Tubulin are presented in a new report. According to news reporting out of Pune, India, by NewsRx editors, research stated, “Aggregation of Microtubule-associated protein Tau and its deposition in the form of neurofibrillary tangles (NFTs) is one of the pathological hallmarks of Alzheimer’s disease (AD). Tau aggregation inhibition has been targeted in various studies including natural compounds and synthetic small molecules.”

Financial support for this research came from Council of Scientific and Industrial Research, India.

Our news journalists obtained a quote from the research from CSIR - National Chemical Laboratory, “Here, we have studied neurohormone-Melatonin against in vitro Tau aggregation and observed its effect on membrane topology, tubulin network and Tau phosphorylation in Neuro2A and N9 cell lines. The aggregation and conformation of Tau was determined by ThT fluorescence and CD spectroscopy respectively. The morphology of Tau aggregates in presence and absence of Melatonin was studied by transmission electron microscopy. Melatonin was found to reduce the formation of higher order oligomeric structures without affecting the overall aggregation kinetics of Tau. Melatonin also modulates and helps to maintain membrane morphology, independent on tubulin network as evidenced by FE-SEM and immunofluorescence analysis.”

According to the news editors, the research concluded: “Overall, Melatonin administration shows mild anti-aggregation and cytoprotective effects.”

For more information on this research see: Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology. International Journal of Biological Macromolecules, 2020;152():30-39. International Journal of Biological Macromolecules can be contacted at: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - http://www.journals.elsevier.com/international-journal-of-biological-macromolecules/)

Our news journalists report that additional information may be obtained by contacting A.A. Balmik, Neurobiology Group, Division of Biochemical Sciences, CSIR - National Chemical Laboratory, Dr Homi Bhabha Road, 411008 Pune, India. Additional authors for this research include R. Das and S. Chinnathambi.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ijbiomac.2020.01.296. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the International Journal of Biological Macromolecules is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

(Our reports deliver fact-based news of research and discoveries from around the world.)