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Schisandra compound improves learning and memory by reducing phosphorylation of tau protein in the hippocampus in mice

Pain & Central Nervous System Daily News

2020 MAY 05 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. According to news originating from Jilin, People’s Republic of China, by NewsRx correspondents, research stated, “Memory disorders are the main symptoms of aging and Alzheimer’s disease and seriously affect the quality of life. Schisandra, as a famous traditional Chinese medicine, has been used for modulating ‘the internal organs’ for a thousand years.”

Financial supporters for this research include Natural ScienceFoundation of Jilin Province, Education Department of Jilin Province, Health Department of Jilin Province.

Our news journalists obtained a quote from the research from Beihua University, “The total lignans from Schisandra have been scientifically proved to improve learning and memory ability. Since it is unclear which monomer in Schisandra total lignans exerts such a function, we evaluated the potential effects of Schisantherin A (SCA), the main monomer from Schisandra, on improving learning ability and memory in amyloid beta-protein (A beta(1.)(42))-induced Alzheimer’s disease (AD) model mice. We found that SCA (5 mg/kg) significantly prolonged the latency and reduced the number of errors in a step-through test. SCA significantly shortened the time of finding the platform and increased the number of crossing the platform and the residence time in a Morris water maze test. SCA increased superoxide dismutase activities and reduced the Malondialdehyde level of the hippocampal tissue, suggesting its role in reducing oxidative stress in the AD mice. Furthermore, we found that SCA significantly decreased the hyperphosphorylation of Tau by altering glycogen synthase kinase-3 beta (GSK-3 beta) phosphorylation on Tyr216 and Ser9.”

According to the news editors, the research concluded: “Our results revealed the mechanism underlying SCA-mediated learning and memory improvement by regulating GSK-3 beta activity and lowering the hyperphosphorylation of Tau protein in the hippocampus of AD mice.”

For more information on this research see: Schisantherin a Improves the Learning and Memory By Reducing the Phosphorylation of Tau Protein of the Hippocampus In Ad Mice. Natural Product Communications, 2020;15(3):. Natural Product Communications can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA.

The news correspondents report that additional information may be obtained from C.M. Wang, Beihua University, College of Pharmacy, Dept. of Pharmacology, Jilin 132013, Jilin, People’s Republic of China. Additional authors for this research include S. Jing, C. Liu, H.J. Lin, X.Y. Zhang, F. Wang, J.Q. Gao, J.H. Sun, J.G. Chen and H. Li.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1177/1934578X19900687. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)