Daily News

Daily News

Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau

Health & Medicine Daily

2020 OCT 22 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Investigators publish new report on Peptides and Proteins - Amyloid. According to news reporting out of Porto Alegre, Brazil, by NewsRx editors, research stated, “Alzheimer’s disease is a progressive neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (Ab) peptide, which induces synaptic dysfunction, alteration of intracellular signaling pathways, hyperphosphorylation of the Tau protein, and cognitive impairment. Genistein, one of the major isoflavones present in soy and soy products, has been shown to modulate some of the pathogenic events associated with the neurodegeneration process.”

Our news journalists obtained a quote from the research from Federal University Rio Grande do Sul, “However, its underlying mechanisms remain to be clarified. Therefore, the objectives of the present study were to evaluate the ability of genistein to protect against Ab-induced cognitive impairment in rats and to elucidate some of the possible mechanisms involved in its neuroprotective effects in the hippocampus. Male Wistar rats received bilateral intracerebroventricular infusions of Ab (2 nmol) and genistein 10 mg/kg orally for 10 days. The Ab-infused animals showed significant impairment of memory, which was accompanied by the following neurochemical alterations in the hippocampus: decreased levels of the synaptic proteins synaptophysin and PSD-95, hyperphosphorylation of Tau with increased activation of GSK-3b and JNK, and inactivation of ERK. Treatment with genistein improved Ab-induced cognitive impairment by attenuation of synaptotoxicity, hyperphosphorylation of Tau, and inactivation of ERK. Furthermore, treatment with this soy isoflavone did not cause systemic toxicity.”

According to the news editors, the research concluded: “These findings provide further evidence of the neuroprotective effect of genistein in an in vivo model of Ab toxicity and, importantly, extend the current knowledge concerning the mechanisms associated with the neuroprotective effects of this compound in the hippocampus.”

This research has been peer-reviewed.

For more information on this research see: Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of Nutritional Biochemistry, 2020:108525. The Journal of Nutritional Biochemistry can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA.

Our news journalists report that additional information may be obtained by contacting Fernanda Dos Santos Petry, Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de Ciencias Basicas da Saude, Federal University Rio Grande do Sul, Porto Alegre, RS, Brazil. Additional authors for this research include Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego and Vera Maria Treis Trindade.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.jnutbio.2020.108525. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the The Journal of Nutritional Biochemistry is: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)