Daily News

Daily News

Sixth affiliated hospital researchers broaden understanding of osteoporosis

Stem Cell Daily

2021 MAY 06 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Daily -- Research findings on osteoporosis are discussed in a new report. According to news reporting out of the Sixth Affiliated Hospital by NewsRx editors, research stated, “With aging, an imbalance in bone remodeling leading to increased bone resorption and decreased bone formation is thought to contribute to osteoporosis. Osteoblastic differentiation of bone marrow mesenchymal stem cells (BMMSCs) plays a vital role in the pathogenesis of osteoporosis.”

The news journalists obtained a quote from the research from Sixth Affiliated Hospital: “However, the detailed molecular mechanisms of osteoporosis remain incompletely understood. Given that long non-coding RNA taurine upregulated gene 1 (lnc TUG1) plays a critical role in the osteogenic differentiation, and microRNA-23b (miR-23b) as a putative sponge for lnc TUG1 has upregulated expression in osteoporosis. Therefore, this study investigated the roles of TUG1/miR-23b in osteoporotic pathology. TUG1 and miR-23b expression in the plasma of osteoporotic patients were evaluated by quantitative real-time PCR (qRT-PCR). The osteogenic differentiation in human BMMSCs was evaluated by qRT-PCR, western blot, Alizarin red staining after knockdown of TUG1 by small interfering RNA (siRNA) treatment. Decreased expression of TUG1 and increased expression of miR-23b evident in the plasma of patients with osteoporosis than in that of age- and sex-matched healthy controls. Additionally, increased miR-23b expression inhibited runt-related transcription factor 2 (RUNX2), osteocalcin, and osteopontin expression and reduced calcified nodule formation based on the results of qRT-PCR, western blot, and Alizarin Red S staining.”

According to the news reporters, the research concluded: “The study for the first time reported that silence of lncRNA TUG1 significantly suppressed the osteogenic differentiation of BMMSCs possibly by targeting the miR-23b/RUNX2 signaling pathway. This mechanism of TUG1/miR-23b/RUNX2 signaling within the osteogenic differentiation of BMMSCs might provide new insight for the development of lncRNA-directed diagnostic and therapeutic strategies for osteoporosis.”

For more information on this research see: Long non-coding RNA taurine upregulated gene 1 is downregulated in osteoporosis and influences the osteogenic differentiation of bone marrow mesenchymal stem cells. PeerJ, 2021,9():e11251. (PeerJ - https://peerj.com/). The publisher for PeerJ is PeerJ Inc.

A free version of this journal article is available at https://doi.org/10.7717/peerj.11251.

Our news editors report that additional information may be obtained by contacting Zhaowei Teng, Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, People’s Republic of China. Additional authors for this research include Yun Zhu, Qinggang Hao, Xiaochao Yu, Yirong Teng, Qiaoning Yue, Xiguang Zhang, Sheng Lu.

(Our reports deliver fact-based news of research and discoveries from around the world.)