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Oxidative stress, neuroinflammation and NADPH oxidase

Pain & Central Nervous System Daily News

2021 MAY 12 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Investigators publish new report on Alzheimer disease. According to news reporting out of the Department of Biochemistry by NewsRx editors, research stated, “NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has gained enormous importance over the years, and the detailed structures of all the isoenzymes of the NADPH oxidase family and their regulation have been well explored.”

Our news journalists obtained a quote from the research from Department of Biochemistry: “The enzyme has been implicated in a variety of diseases including neurodegenerative diseases. The present brief review examines the body of evidence that links NADPH oxidase with the genesis and progression of Alzheimer’s disease (AD). In short, evidence suggests that microglial activation and inflammatory response in the AD brain is associated with increased production of ROS by microglial NADPH oxidase. Along with other inflammatory mediators, ROS take part in neuronal degeneration and enhance the microglial activation process.”

According to the news reporters, the research concluded: “The review also evaluates the current state of NADPH oxidase inhibitors as potential disease-modifying agents for AD.”

For more information on this research see: Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity, 2021,2021. (Oxidative Medicine and Cellular Longevity - https://www.hindawi.com/journals/omcl/). The publisher for Oxidative Medicine and Cellular Longevity is Hindawi Limited.

A free version of this journal article is available at https://doi.org/10.1155/2021/7086512.

Our news editors report that additional information may be obtained by contacting Upasana Ganguly, Department of Biochemistry.

(Our reports deliver fact-based news of research and discoveries from around the world.)