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Low DHEA, testosterone, androstenedione in serum of patients with benign prostatic hyperplasia (BPH)

Health & Medicine Daily

2020 JUN 01 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Research findings on Urogenital Diseases and Conditions - Prostatic Hyperplasia are discussed in a new report. According to news reporting originating from Xuzhou, People’s Republic of China, by NewsRx correspondents, research stated, “Benign prostate hyperplasia (BPH) is a common disease in elderly men. It has been found that the occurrence of BPH was closely related to dysregulated steroid hormones.”

Financial support for this research came from National Natural Science Foundation of China.

Our news editors obtained a quote from the research from the Affiliated Hospital of Xuzhou Medical University, “Here, a rapid, sensitive, accurate and specific method for the quantitative profiling of five androgens in man serum was developed and validated by the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS). Using this method, dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T), androsterone (A), dihydrotestosterone (DHT), oestrone (E1) and oestradiol (E2) were quantified in serum from man with and without BPH. BPH patients were characterised by the decreases in DHEA, A4 and T as well as increases in DHT, E2 and E1 in serum. Meanwhile, DHEA and DHT in serum were screened as sensitive biomarkers of BPH patients.”

According to the news editors, the research concluded: “This study will provide a new perspective of dysregulated steroid hormones for the diagnosis and prevention of BPH.”

For more information on this research see: Simultaneous quantification of oestrogens and androgens in the serum of patients with benign prostatic hyperplasia by liquid chromatography-Tandem mass spectrometry. Andrologia, 2020;():e13611. Andrologia can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - http://www.wiley.com/; Andrologia - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1439-0272)

The news editors report that additional information may be obtained by contacting Y. Huang, Dept. of Pharmacy, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China. Additional authors for this research include T. Yang, Y. Zhou, S. Chen, H. Wang, Y. Hu, J. Liu, Z. Jiang, Q. Lu and X. Yin.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/and.13611. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Andrologia is: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)