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Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis

Gene Therapy Daily News

2020 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Daily News -- A new study on Musculoskeletal Diseases and Conditions - Osteoporosis is now available. According to news originating from Menoufia, Egypt, by NewsRx correspondents, research stated, “Age-dependent male osteoporosis remains a poorly studied medical problem despite its significance. It is estimated that at least 1 of 5 men will suffer from osteoporotic consequences.”

Our news journalists obtained a quote from the research from Menoufia University, “Given that multiple mechanisms are involved in the process of senescence, much attention has been given to compounds with polymodal actions. To challenge such a health problem, we tested here the therapeutic potential of resveratrol in male osteoporosis. We also studied the possible molecular mechanisms that may underlie resveratrol effects. Thirty male Wistar albino rats were used in the present study. Rats were divided (10/group) into: control (3-4 months old weighing 150-200 g receiving vehicle), aged (18-20 months old, weighing 350-400 g and receiving vehicle), and resveratrol treated aged (18-20 months old, weighing 350-400 g and receiving resveratrol 20 mg/kg/day for 6 weeks) groups. Assessment of serum calcium, phosphate, bone specific alkaline phosphatase, inflammatory cytokines, oxidative stress markers, and rat femur gene expression of FoxO1, SIRT1, RANKL and OPG proteins was carried out. Histopathological assessment of different levels of rat femur was also performed. Age-dependent osteoporosis resulted in significant increase in serum levels of phosphate, bone specific alkaline phosphatase, hsCRP, IL-1b, IL-6, TNF-a, MDA, NO, and RANKL gene expression. However, there was significant decrease in serum level of GSH, and gene expression of FoxO1, SIRT1 and OPG. Osteoporotic changes were seen in femur epiphysis, metaphysis and diaphysis. Resveratrol restored significantly age-dependent osteoporotic changes. We concluded that resveratrol can play an important role in the prevention of male osteoporosis.”

According to the news editors, the research concluded: “Resveratrol can counter the molecular changes in male osteoporosis via anti-inflammatory, anti-oxidant and gene modifying effects.”

For more information on this research see: Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. Bmc Musculoskeletal Disorders, 2020;21(1):375. Bmc Musculoskeletal Disorders can be contacted at: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England. (BioMed Central - http://www.biomedcentral.com/; Bmc Musculoskeletal Disorders - http://www.biomedcentral.com/bmcmusculoskeletdisord/)

The news correspondents report that additional information may be obtained from R.I. Yassien, Histology and Cell Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt. Additional authors for this research include O. Ameen and Y.M Naguib.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1186/s12891-020-03389-w. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher’s contact information for the journal Bmc Musculoskeletal Disorders is: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England.

(Our reports deliver fact-based news of research and discoveries from around the world.)