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Curcumin protects bone biomechanical properties and microarchitecture in type 2 diabetic rats with osteoporosis

Chemicals & Chemistry Daily

2020 SEP 17 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- Research findings on Musculoskeletal Diseases and Conditions - Osteoporosis are discussed in a new report. According to news reporting originating in Guangdong, People’s Republic of China, by NewsRx journalists, research stated, “Type 2 diabetic osteoporosis (T2DOP) has become a common secondary cause of osteoporosis that accelerates bone loss and leads to bone fractures. The aim of the current study was to investigate the association between the anti-osteoporotic effect of curcumin (Cur) and the transforming growth factor (TGF)beta /Smads signaling pathway.”

Funders for this research include Zhaoqing Medical College 2017 Annual University-Level Research Project, 2019 Guangdong Medical Research Fund Project, Science and Technology Million Project Joint Project of Inner Mongolia Medical University, Medical Health Science and Technology Project of Baotou Inner Mongolia.

The news reporters obtained a quote from the research from the Department of Pharmacy, “Male Sprague-Dawley rats were used in the experiments. The type 2 diabetes mellitus (T2DM) animals were treated with Cur for 8 weeks and blood lipid markers, bone microstructure and bone biomechanics were then evaluated. The mRNA expression levels of TGF beta 1, type I TGF beta receptor (T beta RI), T beta RII and Smad2/3 were determined using reverse transcription-quantitative PCR (RT-qPCR) and immunohistochemistry. The body weight of rats with type 2 diabetes-induced osteoporosis increased (P <0.05), while the lipid (total cholesterol, triglyceride and low-density lipoprotein) and fasting blood glucose levels were decreased by Cur (P <0.05). In addition, Cur significantly improved bone biomechanical properties (maximum load, breaking load, elastic load and the bone rigidity coefficient) and preserved bone microarchitecture (P <0.05). The RT-qPCR and IHC results revealed that Cur increased TGF <beta >1, T beta RI, T beta RII and Smad2/3 expression levels and promoted Smad2/3 phosphorylation in bones.”

According to the news reporters, the research concluded: “The present results also indicated that Cur regulated lipid and glucose levels, improved bone biomechanical properties and preserved bone microarchitecture, and that these effects may be mediated via TGF beta /Smad2/3 pathway activation.”

For more information on this research see: Curcumin Protects Bone Biomechanical Properties and Microarchitecture In Type 2 Diabetic Rats With Osteoporosis Via the Tgf Beta/smad2/3 Pathway. Experimental and Therapeutic Medicine, 2020;20(3):2200-2208. Experimental and Therapeutic Medicine can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece.

Our news correspondents report that additional information may be obtained by contacting Yuan Zeng, Peoples Hosp Nanxiong, Dept. of Pharmacy, 49 Yangjiang Rd, Shaoguan 512400, Guangdong, People’s Republic of China. Additional authors for this research include Yanlong Liang, Yun Zhai, Yiqiu Yang, Benben Zhu, Zaixian Bai, Shuhui Li and Dawei Li.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3892/etm.2020.8943. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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