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Quercetin reduces tendon adhesion in rat through suppression of oxidative stress

Health & Medicine Daily

2020 SEP 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Research findings on Diseases and Conditions - Musculoskeletal Disorders are discussed in a new report. According to news reporting originating from Yangzhou, People’s Republic of China, by NewsRx correspondents, research stated, “Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, including anti-inflammatory, anti-ischemic, anti-peroxidation, and antioxidant.”

Funders for this research include National Natural Science Foundation of China, Graduate Research and Innovation Projects of Jiangsu Province.

Our news editors obtained a quote from the research from the Clinical Medical College of Yangzhou University, “The purpose of this study was to investigate the effect of quercetin on tendon adhesion and whether quercetin can inhibit oxidative stress. Thirty-six rats were randomly divided into three groups, including control group, low QUE (50 mg/kg/day) group, and high QUE (100 mg/kg/day) group. After 1 week, the levels of SOD, MDA and GPx were measured. The degree of tendon adhesion was assessed by macroscopic evaluation and histological evaluation. After 4 weeks. Besides, the pharmacological toxicity of quercetin to main organs were evaluated by histological analysis. The extent of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of tendon tissue in high QUE group was significantly higher than those of low QUE group and control group. And the extent of malondialdehyde (MDA) of tendon tissue in high QUE group was significantly lower than that of low QUE group and control group. By macroscopic evaluation and histological analysis, the extent of tendon adhesion in high QUE group was lower than low QUE group and control group. However, there were no significant changes of the major organs through histological analysis. Quercetin may be a good and safe strategy in preventing tendon adhesion.”

According to the news editors, the research concluded: “But further clinical research is needed before its recommendation in the prevention and treatment of tendon adhesion.”

For more information on this research see: Quercetin reduces tendon adhesion in rat through suppression of oxidative stress. Bmc Musculoskeletal Disorders, 2020;21(1):608. Bmc Musculoskeletal Disorders can be contacted at: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England. (BioMed Central - http://www.biomedcentral.com/; Bmc Musculoskeletal Disorders - http://www.biomedcentral.com/bmcmusculoskeletdisord/)

The news editors report that additional information may be obtained by contacting Keteng Xu, Dept. of Orthopedics, Clinical Medical College of Yangzhou University, Subei People’s Hospital, Nantong West Road 98, Yangzhou, 225001, People’s Republic of China. Additional authors for this research include Yuan Liang, Pei Zhang, Jiale Zhang, Pengtao Chen, Jinshan He, Yongchao Fang, Yuelai Zhou, Jingcheng Wang and Jianzhong Bai.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1186/s12891-020-03618-2. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Bmc Musculoskeletal Disorders is: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England.

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