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Aspirin use associated with significantly decreased incidence of uterine cancer in a retrospective population-based study

Taiwan Daily Report

2020 SEP 22 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- Investigators publish new report on Oncology - Uterine Cancer. According to news reporting out of Hualien, Taiwan, by NewsRx editors, research stated, “Aspirin (ASA) exerts an anti-tumor effect via the COX pathway. Clinical studies on the chemopreventive effects of ASA on uterine cancer (UC) remain inconsistent.”

Funders for this research include Taiwan Ministry of Health and Welfare Clinical Trial Center, China Medical University Hospital, Academia Sinica Stroke Biosignature Project, MOST Clinical Trial Consortium for Stroke, Tseng-Lien Lin Foundation, Taichung, Taiwan, Katsuzo and Kiyo Aoshima Memorial Funds, Japan.

Our news journalists obtained a quote from the research from Hualien Tzu Chi Hospital, “We used population-based retrospective cohort study to evaluate the UC in ASA users in Taiwanese women. From insurance claims data, we identified 23,342 women received ASA treatment between 2000 and 2010 and a comparison group of same sample size randomly selected from the same database matched by the propensity score. The incidence of UC in the ASA cohort was 10% of that in the comparison group (0.28 vs 2.73 per 10,000 person-years). The Poisson regression analysis estimated adjusted incidence rate ratio (IRR) was 0.10 (95% confidence interval (CI) = 0.09-0.11) for ASA users relatives to comparisons after controlling for covariates. The UC incidence in ASA users decreased with age, from 0.61 per 10,000 person-years in the 20 to 39 years old (adjusted IRR = 0.21, 95% CI = 0.15-0.29) to 0.21 per 10,000 person-years in the 65 to 80 years old (adjusted IRR = 0.15, 95% CI = 0.12-0.16). The incidence was higher in longer term users. Hormone therapy of estradiol was associated with the increase of UC risk in both cohorts, but less in ASA users than comparisons (1.34 vs 4.75 per 10,000 person-years). This study suggests that ASA use was associated with a decreased risk of UC.”

According to the news editors, the research concluded: “Further prospective randomized clinical trials are warranted to confirm the association.”

For more information on this research see: Aspirin Associated With a Decreased Incidence of Uterine Cancer a Retrospective Population-based Cohort Study. Medicine, 2020;99(31):. Medicine can be contacted at: Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Elsevier - www.elsevier.com; Medicine - http://www.journals.elsevier.com/medicine/)

Our news journalists report that additional information may be obtained by contacting Dah-Ching Ding, Buddhist Tzu Chi Medical Foundation, Hualien Tzu Chi Hospital, Dept. of Obstetrics and Gynecology, 707 Chung Yang Rd, Sec 3, Hualien, Taiwan. Additional authors for this research include Pei-Chen Li, Jen-Hung Wang, Shinn-Zong Lin, Fung-Chang Sung, Yu-Cih Yang and Weishan Chen.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1097/MD.0000000000021446. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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