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National Institute of Allergy and Infectious Diseases (NIAID) provides new data about inflammatory bowel disease

Gastroenterology Daily News

2021 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Daily News -- Current study results on Digestive System Diseases and Conditions - Inflammatory Bowel Disease have been published. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, “Interleukin (IL)-37, an antiinflammatory IL-1 family cytokine, is a key suppressor of innate immunity. IL-37 signaling requires the heterodimeric IL-18R1 and IL-1R8 receptor, which is abundantly expressed in the gastrointestinal tract.”

Financial support for this research came from NIH National Institute of Allergy & Infectious Diseases (NIAID).

The news correspondents obtained a quote from the research from the National Institute of Allergy and Infectious Diseases (NIAID), “Here we report a 4-mo-old male from a consanguineous family with a homozygous loss-of-function IL37 mutation. The patient presented with persistent diarrhea and was found to have infantile inflammatory bowel disease (I-IBD). Patient cells showed increased intracellular IL-37 expression and increased proinflammatory cytokine production. In cell lines, mutant IL-37 was not stably expressed or properly secreted and was thus unable to functionally suppress proinflammatory cytokine expression. Furthermore, induced pluripotent stem cell-derived macrophages from the patient revealed an activated macrophage phenotype, which is more prone to lipopolysaccharide and IL-1 beta stimulation, resulting in hyperinflammatory tumor necrosis factor production.”

According to the news reporters, the research concluded: “Insights from this patient will not only shed light on monogenic contributions of I-IBD but may also reveal the significance of the IL-18 and IL-37 axis in colonic homeostasis.”

This research has been peer-reviewed.

For more information on this research see: Homozygous Il37 Mutation Associated With Infantile Inflammatory Bowel Disease. Proceedings of the National Academy of Sciences, 2021;118(10). Proceedings of the National Academy of Sciences can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - http://www.nasonline.org/; Proceedings of the National Academy of Sciences - http://www.nasonline.org/publications/pnas/)

Our news journalists report that additional information may be obtained by contacting Michael J. Lenardo, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, United States. Additional authors for this research include Zinan Z. Zhang, Yu Zhang, Tingyan He, Colin L. Sweeney, Yikun Yao, Helen F. Matthews, Harry L. Malech, Helen C. Su, Kenneth G. C. Smith, Safa Baris, Elif Karakoc-Aydiner, Deniz Ertem, Ahmet Ozen and Claudia Gonzaga-Jauregui.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1073/pnas.2009217118. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)