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Researchers at Ministry of Health target transforming growth factors

NewsRx Cardiovascular Daily

2021 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- Investigators publish new report on Intercellular Signaling Peptides and Proteins - Transforming Growth Factors. According to news originating from Moscow, Russia, by NewsRx correspondents, research stated, “We evaluated the content of active form of TGF-beta 1 in the intact and post-infarction heart and the effect of this factor on the properties of epicardial cells.”

Funders for this research include Russian Science Foundation (RSF), Russian Foundation for Basic Research (RFBR).

Our news journalists obtained a quote from the research from the Ministry of Health, “During the acute stage after myocardial infarction, the production of TGF-beta 1 in the heart increased, which closely correlated with activation of epicardial cells (appearance of a pool of Wt1+ epicardial cells entering the epithelial-mesenchymal transition). The role of TGF-beta 1 as the factor of epicardial activation was confirmed by the results of in vitro experiments: addition of recombinant TGF-beta 1 to cultured epicardial cells led to enhanced expression of genes of epithelial-mesenchymal transition and phenotypic transformation of these cells leading to the appearance of cells with markers of smooth muscle cells and fibroblasts.”

According to the news editors, the research concluded: “Our findings suggest that the regulatory axis ‘TGF-beta 1-epicardium cells’ can be considered as an important link of the post-infarction reparative process and adaptive response during heart remodeling after myocardial infarction and as the target for therapeutic interventions.”

This research has been peer-reviewed.

For more information on this research see: Transforming Growth Factor Beta (Tgf-beta 1) Induces Pro-reparative Phenotypic Changes In Epicardial Cells In Mice. Bulletin of Experimental Biology and Medicine, 2021;170(4):565-570. Bulletin of Experimental Biology and Medicine can be contacted at: Springer, One New York Plaza, Suite 4600, New York, Ny, United States. (Springer - www.springer.com; Bulletin of Experimental Biology and Medicine - http://www.springerlink.com/content/0007-4888/)

The news correspondents report that additional information may be obtained from K. Dergilev, Ministry of Health, Inst Expt Cardiol, Lab Angiogenesis, National Medical Research Centre for Cardiology, Moscow, Russia. Additional authors for this research include Z. Tsokolaeva, I. B. Beloglazova, E. Ratner and E. Parfenova.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10517-021-05107-5. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)