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Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis

Daily Hong Kong Daily

2021 MAY 04 (NewsRx) -- By a News Reporter-Staff News Editor at Daily Hong Kong Report -- New research on Musculoskeletal Diseases and Conditions - Osteoporosis is the subject of a report. According to news reporting from Hong Kong, People’s Republic of China, by NewsRx journalists, research stated, “Osteoporosis is characterized by reductions in bone mass, which could be attributed to the dysregulation of bone homeostasis, such as the loss of balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Elevated levels of oxidative stress increase bone resorption by promoting osteoclastogenesis and inhibiting the osteogenesis.”

The news correspondents obtained a quote from the research from the Chinese University of Hong Kong, “Ginkgolide B (GB), a small natural molecule from Ginkgo biloba, has been reported to possess pharmacological activities by regulating reactive oxygen species (ROS) in aging-related degenerative diseases. Herein, we assessed the therapeutic effects of GB on the bone phenotypes of mice with osteoporosis induced by (I) aging, (II) ovariectomy, and (III) glucocorticoids. In all three animal models, oral gavage of GB significantly improved bone mass consistent with the increase in the OPG-to-RANKL ratio. In the in vitro experiments, GB promoted osteogenesis in aged mesenchymal stem cells (MSCs) and repressed osteoclastogenesis in aged macrophages by reducing ROS. The serum protein profile in GB-treated aged mice revealed moderate rejuvenating effects; signaling pathways associated with ROS were also regulated. The anabolic and anti-catabolic effects of GB were illustrated by the reduction in ROS. Our results indicate that GB is effective in treating osteoporosis.”

According to the news reporters, the research concluded: “The use of GB in patients with osteoporosis is worthy of further clinical investigation.”

This research has been peer-reviewed.

For more information on this research see: Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis. Free Radical Biology and Medicine, 2021;168:234-246. Free Radical Biology and Medicine can be contacted at: Elsevier Science Inc, Ste 800, 230 Park Ave, New York, NY 10169, USA. (Elsevier - www.elsevier.com; Free Radical Biology and Medicine - http://www.journals.elsevier.com/free-radical-biology-and-medicine/)

Our news journalists report that additional information may be obtained by contacting Chien-Wei Lee, Institute for Tissue Engineering and Regenerative Medicine, Chinese University of Hong Kong, Hong Kong SAR, 999077, People’s Republic of China. Additional authors for this research include Hui-Chu Lin, Belle Yu-Hsuan Wang, Amanda Yu-Fan Wang, Rita Lih-Ying Shin, Stella Yee Lo Cheung and Oscar Kuang-Sheng Lee.

Publisher contact information for the journal Free Radical Biology and Medicine is: Elsevier Science Inc, Ste 800, 230 Park Ave, New York, NY 10169, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)