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Association of small intestinal bacterial overgrowth with Parkinson’s disease

Pain & Central Nervous System Daily News

2021 MAY 04 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Current study results on Parkinson’s disease have been published. According to news reporting originating from First Affiliated Hospital of Chongqing Medical University by NewsRx correspondents, research stated, “Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease (AD) worldwide. The prevalence of small intestinal bacterial overgrowth (SIBO) in PD patients is high. We conducted this comprehensive systematic review and meta-analysis to determine the association between SIBO and PD.”

The news reporters obtained a quote from the research from First Affiliated Hospital of Chongqing Medical University: “A comprehensive literature search of the PubMed, Cochrane Library and EMBASE databases was performed to identify studies correlating SIBO with PD. Studies were screened, and relevant data were extracted and analysed. We calculated the pooled prevalence of SIBO in all individuals with PD and compared the prevalence of SIBO between the two groups to calculate an odds ratio (OR) and 95% confidence interval (CI). Egger’s test was performed to assess publication bias. Eleven studies with 973 participants met the inclusion criteria. The pooled prevalence of SIBO in patients with PD was 46% (95% CI 36-56). A random-effects model was applied given the heterogeneity (I2 = 83%) detected among the studies. Egger’s test indicated no publication bias (p = 0.0657). Subgroup analyses showed that the prevalence of SIBO was greater in studies including patients diagnosed using the lactulose hydrogen breath test (LBT) (51%, 95% CI 37-65) than in those including patients diagnosed using the glucose hydrogen breath test (GBT) (35%, 95% CI 20-50), and the prevalence of SIBO in PD was highest (55%, 95% CI 38-72) in patients diagnosed by the LBT and GBT. The prevalence of SIBO was 52% (95% CI 40-64) among patients from Western countries and 33% (95% CI 22-43) among patients from Eastern countries. The pooled OR of SIBO in PD patients compared with healthy controls was 5.22 (95% CI 3.33-8.19, p < 0.00001). We did not identify an obvious predictor of SIBO in PD patients.”

According to the news editors, the research concluded: “In conclusion, our meta-analysis found a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO. These relationships significantly differed based on diagnostic test and geographic area.”

For more information on this research see: Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis. Gut Pathogens, 2021,13(1):1-10. (Gut Pathogens - http://www.gutpathogens.com/). The publisher for Gut Pathogens is BMC.

A free version of this journal article is available at https://doi.org/10.1186/s13099-021-00420-w.

Our news journalists report that more information may be obtained by contacting Xiaoqing Li, Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University. Additional authors for this research include Xin Feng, Zhongxiang Jiang, Zheng Jiang.

(Our reports deliver fact-based news of research and discoveries from around the world.)