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Vitamin C modified relation between gastric cancer and Helicobacter pylori

NewsRx.com

04-01-05

Scientists showed that vitamin C modified the relationship between gastric cancer and Helicobacter pylori.

"A hospital-based case-control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between H. pylori infection and gastric cancer in Korea in 1997-1998. Anti-H. pylori IgG was detected by ELISA," researchers in South Korea reported.

To explain their methodology, D.S. Kim and colleagues from Seoul National University replied, "A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered."

"The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI): 1.14, 2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer," said the scientific assembly.

The researchers concluded, "In a stratified analysis, vitamin C intake was found to modify the relation between H. pylori and gastric cancer."

Kim and colleagues published their study in European Journal of Epidemiology (Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori. Eur J Epidemiol, 2005;20(1):67-71).

For additional information, contact Y.O. Ahn, Seoul National University, College Med, Department Prevention Med, 28 Yongon Dong Chongno Gu, Seoul 110799, South Korea.

The publisher's contact information for the European Journal of Epidemiology is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords: Seoul, South Korea, Ascorbic Acid, Case Control Studies, Effect Modifiers, Helicobacter pylori, Stomach Neoplasm, Gastric Cancer, Diet and Nutrition, Gastroenterology and Oncology. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2005, Biotech Week via NewsRx.com.

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