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New Ascorbic Acid Deficiency Findings from University of Otago Reported (Hypovitaminosis C and vitamin C deficiency in critically ill patients...

Proteomics Weekly


New Ascorbic Acid Deficiency Findings from University of Otago Reported (Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes)

By a News Reporter-Staff News Editor at Proteomics Weekly -- Data detailed on Nutritional and Metabolic Diseases and Conditions - Ascorbic Acid Deficiency have been presented. According to news reporting originating in Christchurch, New Zealand, by NewsRx journalists, research stated, "Vitamin C is an essential water-soluble nutrient which cannot be synthesised or stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive roles."

The news reporters obtained a quote from the research from the University of Otago, "Previous research has indicated that vitamin C levels are depleted in critically ill patients. In this study we have assessed plasma vitamin C concentrations in critically ill patients relative to infection status (septic shock or non-septic) and level of inflammation (C-reactive protein concentrations). Vitamin C status was also assessed relative to daily enteral and parenteral intakes to determine if standard intensive care unit (ICU) nutritional support is adequate to meet the vitamin C needs of critically ill patients. Forty-four critically ill patients (24 with septic shock, 17 non-septic, 3 uncategorised) were recruited from the Christchurch Hospital Intensive Care Unit. We measured concentrations of plasma vitamin C and a proinflammatory biomarker (C-reactive protein) daily over 4 days and calculated patients' daily vitamin C intake from the enteral or total parenteral nutrition they received. We compared plasma vitamin C and C-reactive protein concentrations between septic shock and non-septic patients over 4 days using a mixed effects statistical model, and we compared the vitamin C status of the critically ill patients with known vitamin C bioavailability data using a four-parameter log-logistic response model. Overall, the critically ill patients exhibited hypovitaminosis C (i.e., < 23 mu mol/L), with a mean plasma vitamin C concentration of 17.8 +/- 8.7 mu mol/L; of these, one-third had vitamin C deficiency (i. e., < 11 mu mol/L). Patients with hypovitaminosis C had elevated inflammation (C-reactive protein levels; P< 0.05). The patients with septic shock had lower vitamin C concentrations and higher C-reactive protein concentrations than the non-septic patients (P < 0.05). Nearly 40% of the septic shock patients were deficient in vitamin C, compared with 25% of the non-septic patients. These low vitamin C levels were apparent despite receiving recommended intakes via enteral and/or parenteral nutritional therapy (mean 125 mg/d). Critically ill patients have low vitamin C concentrations despite receiving standard ICU nutrition."

According to the news reporters, the research concluded: "Septic shock patients have significantly depleted vitamin C levels compared with non-septic patients, likely resulting from increased metabolism due to the enhanced inflammatory response observed in septic shock."

For more information on this research see: Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care, 2017;21():1-10. Critical Care can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central -; Critical Care -

Our news correspondents report that additional information may be obtained by contacting A.C. Carr, University of Otago, Dept. of Pathol, Christchurch 8140, New Zealand. Additional authors for this research include P.C. Rosengrave, S. Bayer, S. Chambers, J. Mehrtens and G.M. Shaw (see also Nutritional and Metabolic Diseases and Conditions - Ascorbic Acid Deficiency).

Keywords for this news article include: Christchurch, New Zealand, Australia and New Zealand, Nutritional and Metabolic Diseases and Conditions, Blood Diseases and Conditions, Ascorbic Acid Deficiency, Critical Care Medicine, Acute-Phase Proteins, Health and Medicine, C-Reactive Protein, C Reactive Protein, Intensive Care, Immunoproteins, Inflammation, Septic Shock, Immunology, Proteomics, Vitamin C, Albumins, Sepsis, University of Otago.

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