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ED drugs also help with enlarged prostate

Erie Times-News

05-16-18

Q: What is your opinion of using Cialis to treat benign prostatic hyperplasia?

A: Cialis (tadalafil) may be most familiar as an effective drug for erectile dysfunction, similar to other drugs in its class, such as Viagra and Levitra. Because its chemical structure is different, however, it lasts longer in the bloodstream. Tadalafil works by inhibiting a specific enzyme, PDE5, and in doing so increases blood flow.

Epidemiologic studies have noted an association between erectile dysfunction and the lower urinary tract symptoms of benign prostatic hyperplasia, also known as an enlarged prostate. Those symptoms include urinary frequency, urgency, hesitancy and poor stream. Accordingly, PDE5 inhibitors have the potential to help treat not only erectile dysfunction but also BPH.

As for studies assessing the use of Cialis, Viagra and Levitra for BPH, the results have been fairly promising. A 2011 analysis of 11 studies looked at the benefits of PDE5 inhibitors compared with a placebo. Six of the studies used Cialis, four used Viagra and one used Levitra. Participants filled out a questionnaire prior to starting the studies, which lasted eight to 12 weeks, and again at the end. The trials found that the reported symptoms of BPH improved with each of the medications compared to placebo. However, none of the five studies actually assessing urine flow found an improvement with the PDE5 inhibitors, and four failed to show an improvement in the emptying of the bladder.

Later studies, with the use of Cialis specifically, also verified a reduction in urinary symptoms. The greatest benefit came from the use of 5 milligrams of Cialis on a daily basis, with 60 to 79 percent of participants reporting an improvement of symptoms, and more than 50 percent noting an improvement after one week.

A 2012 study in the journal European Urology compared Cialis with the most commonly used drug for BPH, Flomax: 171 patients took Cialis and 167 patients took Flomax. Researchers found significant and near equal improvement of most urinary symptoms. But Cialis didn't improve urine flow, as did Flomax and other alpha-1 blockers. That said, Flomax does not benefit erections.

It might be tempting to combine an alpha-1 blocker like Flomax with Cialis, but the two medications together have the potential to severely lower blood pressure. That's not to say they will. A recent 2017 study, which assessed that specific combination, did not show any significant adverse effects. Clearly, more studies are needed to know if the combination is safe and any better than Flomax alone.

If you have erectile dysfunction and symptoms of enlarged prostate, Cialis can benefit both of those problems.

Clarification: Please note that a recent column on the potential link between peripheral neuropathy and MRI with gadolinium contrast was unclear on the use of an iodine contrast agent. The latter is administered with a CT scan, not MRI, and should be used with caution in those with kidney dysfunction.

Send your questions to askthedoc tors@mednet.ucla.edu, or Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA 90095.

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

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