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New Inflammation Data Have Been Reported by Researchers at Chonbuk National University (Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation)

Drug Week

10-19-18

By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Inflammation have been presented. According to news originating from Iksan, South Korea, by NewsRx correspondents, research stated, "Korean red ginseng (KRG) is a traditional herbal medicine used to prevent several geriatric diseases due to its therapeutic effects on metabolic disorder, including type 2 diabetes and fatty liver disease. In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice."

Our news journalists obtained a quote from the research from Chonbuk National University, "NASH was induced by feeding a methionine-and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Each diet group was also orally administered saline (group G0) or KRG extract (100, 200, or 400 mg/kg/day; groups G1, G2, and G4, respectively). KRG showed anti-inflammatory and antifibrogenic effects in the diet-induced NASH models. Furthermore, the expression levels of lipid metabolism-related genes were markedly decreased with KRG treatment in both diet-induced NASH groups. We next confirmed the expression levels of FABP4 in the liver and its ability to regulate inflammation and/or oxidative stress. We observed decreased levels of FABP4 mRNA and protein in the KRG-treated groups indicating that KRG affects the pathogenesis of NASH-related inflammatory responses by modulating FABP4 expression. Results of in vitro experiments showed similar patterns in cells treated with KRG, indicating that KRG treatment regulates the expression of FABP4 and subsequently reduces NASH related inflammation. Our findings suggest a novel role of KRG in NASH-related inflammatory responses via modulation of FABP4 expression in the liver."

According to the news editors, the research concluded: "KRG may be a safe alternative therapy to prevent NASH progression."

For more information on this research see: Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation. The American Journal of Chinese Medicine, 2018;():1-27. The American Journal of Chinese Medicine can be contacted at: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224 (see also Inflammation).

The news correspondents report that additional information may be obtained from H. Jeong, 1 Biosafety Research Institute and Laboratory of Pathology, (BK21 Plus Program), College of Veterinary Medicine, Chonbuk National University, Iksan, South Korea. Additional authors for this research include J.W. Kim, M.S. Yang, C. Park, J.H. Kim, C.W. Lim and B. Kim.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1142/S0192415X18500817. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher's contact information for the The American Journal of Chinese Medicine is: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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