Antiepileptic drugs linked to higher risk of stroke in persons with Alzheimer's disease
According to another recent study from the same research group, persons with Alzheimer's disease use antiepileptic drugs more often than persons without Alzheimer's disease. The difference was not explained by epilepsy, and there was a considerable increase in antiepileptic drug use around the time when Alzheimer's disease was diagnosed.
Up to 1% of population needs chronic antiepileptic treatment to control epilepsy. Other indications for antiepileptic drug use include neuropathic pain and dementia-related behavioural symptoms in persons with Alzheimer's disease.
The present findings indicate that as persons with Alzheimer's disease are particularly susceptible to adverse events, the use of antiepileptic drugs for other indications than epilepsy or neuropathic pain should be carefully considered in this vulnerable population.
The studies were based on the nationwide register-based MEDALZ cohort that includes all community-dwelling persons with clinically verified diagnosis of Alzheimer's disease in
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