Data on Neurodegeneration Reported by A.R. Mendelsohn and Colleagues (Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration)
Genomics & Genetics Weekly
The news correspondents obtained a quote from the research, "Elimination of senescent cells by pharmacologically induced genetic ablation or by senolytic drugs blocks progression of mutant human tau-mediated neurodegeneration in mice. This work suggests a working hypothesis through which tau activation leads to senescence and then tau propagation throughout the brain is supported by, and neurotoxicity is caused by, SASP, forming a pathological positive feedback loop."
According to the news reporters, the research concluded: "Although preliminary, these data suggest that the development of senolytics for AD and other tauopathies, especially early disease, and possibly senomodulatory drugs for later stage neurodegenerative disease may prove fruitful."
For more information on this research see: Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration.
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The direct object identifier (DOI) for that additional information is: https://doi.org/10.1089/rej.2018.2155. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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