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Findings on Diet and Nutrition Reported by Investigators at Southern Medical University (Plasma 25-hydroxyvitamin D Concentrations Are Inversely Associated With All-cause Mortality Among a Prospective Cohort of Chinese Adults Aged >= 80 Years)

Daily China News

06-24-19

2019 JUN 21 (NewsRx) -- By a News Reporter-Staff News Editor at Daily China News -- Data detailed on Health and Medicine - Diet and Nutrition have been presented. According to news reporting originating from Guangzhou, People’s Republic of China, by NewsRx correspondents, research stated, “High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged >= 80 y (oldest old) remains unclear. We investigated the association between plasma [25(OH)D] concentration and all-cause mortality among Chinese adults aged >= 80 y. The present study is a prospective cohort study of 2185 Chinese older adults (median age: 93 y).”

Financial supporters for this research include National Natural Sciences Foundation of China, U.S. National Institute of Aging, United Nations Fund for Population Activities, A Claude D. Pepper Older Americans Independence Centersgrant (NIA), National Key Research and Development Program of China, Construction of High-level University in Guangdong, National Institutes of Health.

Our news editors obtained a quote from the research from Southern Medical University, “Prospective all-cause mortality data were analyzed for survival in relation to plasma 25(OH)D using Cox proportional hazards regression models, with adjustments for potential sociodemographic and lifestyle confounders and biomarkers. The associations were measured with HR and 95% CIs. The median plasma 25(OH)D concentration was 34.4 nmol/L at baseline. Over the 5466 person-year follow-up period, 1100 deaths were identified. Men and women were analyzed together as no effect modification by sex was found. After adjusting for multiple potential confounders, the risk of all-cause mortality decreased as the plasma 25(OH)D concentration increased (P-trend <0.01). Compared with the lowest age-specific quartile of plasma 25(OH)D, the adjusted HRs for mortality for the second, third, and fourth age-specific quartiles were 0.72 (95% CI: 0.57, 0.90), 0.73 (95% CI: 0.58, 0.93), and 0.61 (95% CI: 0.47, 0.81), respectively. The observed associations were broadly consistent across age and other subgroups. Sensitivity analyses generated similar results after excluding participants who died within 2 y of follow-up or after further adjustment for ethnicity and chronic diseases.”

According to the news editors, the research concluded: “A higher plasma 25-hydroxyvitamin D concentration was associated with a reduced risk of all-cause mortality among Chinese adults aged >= 80 y. This observed inverse association warrants further investigation in randomized controlled trials testing vitamin D supplementation in this age group.”

For more information on this research see: Plasma 25-hydroxyvitamin D Concentrations Are Inversely Associated With All-cause Mortality Among a Prospective Cohort of Chinese Adults Aged >= 80 Years. Journal of Nutrition, 2019;149(6):1056-1064. Journal of Nutrition can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England.

The news editors report that additional information may be obtained by contacting X.B. Wu, Southern Medical University, Dept. of Epidemiology, Guangdong Prov Key Lab Trop Dis Res, School of Public Health, Guangzhou, Guangdong, People’s Republic of China. Additional authors for this research include C. Mao, F.R. Li, J.Q. Yuan, F. Mhungu, Z.X. Yin, Y.B. Lv, J.N. Wang, W.Y. Shi, J.H. Zhou, X.M. Shi, J.S. Luo, G.C. Chen, X. Gao and V.B. Kraus.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1093/jn/nxz041. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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