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Studies from National Taiwan Normal University Yield New Information about Alzheimer Disease (Protective Effect of Caffeic Acid Against Alzheimer’s Disease Pathogenesis Via Modulating Cerebral Insulin Signaling, Beta-amyloid Accumulation, and ...)

Taiwan Daily Report


2019 AUG 06 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- Current study results on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been published. According to news reporting originating in Taipei, Taiwan, by NewsRx journalists, research stated, “This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer’s disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated.”

Financial support for this research came from National Science Council, Taiwan.

The news reporters obtained a quote from the research from National Taiwan Normal University, “CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3 beta (GSK3 beta) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and beta-site APP cleaving enzyme were attenuated, subsequently lowering the level of beta-amyloid 1-42 (A beta 1-42) in the hippocampus of CA-treated hyperinsulinemic rats.”

According to the news reporters, the research concluded: “CA also significantly increased the expression of synaptic proteins in HF rats.”

For more information on this research see: Protective Effect of Caffeic Acid Against Alzheimer’s Disease Pathogenesis Via Modulating Cerebral Insulin Signaling, Beta-amyloid Accumulation, and Synaptic Plasticity In Hyperinsulinemic Rats. Journal of Agricultural and Food Chemistry, 2019;67(27):7684-7693. Journal of Agricultural and Food Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Journal of Agricultural and Food Chemistry -

Our news correspondents report that additional information may be obtained by contacting Z.C. Shen, National Taiwan Normal University, Grad Program Nutr Sci, 162, Sec 1, Heping East Rd, Taipei 10610, Taiwan. Additional authors for this research include W.C. Chang, D.W. Huang, Y.M. Lo, Q.Q. Tee, P. Kuo, J.S. Wu and W.C. Huang.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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