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Findings from Ardabil University of Medical Sciences in Brain Edema Reported (Magnesium Sulfate Protects Blood-brain Barrier Integrity and Reduces Brain Edema After Acute Ischemic Stroke In Rats)

Middle East Daily


2019 AUG 08 (NewsRx) -- By a News Reporter-Staff News Editor at Middle East Daily -- Investigators discuss new findings in Central Nervous System Diseases and Conditions - Brain Edema. According to news reporting originating in Ardebil, Iran, by NewsRx journalists, research stated, “Brain edema is a fatal complication of acute ischemic stroke and associated with worse outcomes in patients. This study was designed to evaluate the effects of magnesium sulfate on vasogenic brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia-reperfusion (IR) in a rat model of ischemic stroke.”

Financial support for this research came from Ardabil University of Medical Sciences, Ardabil, Iran.

The news reporters obtained a quote from the research from the Ardabil University of Medical Sciences, “A total of 72 male Sprague-Dawley rats were categorized into the following three primary groups: sham, control ischemic, magnesium-sulfate-treated (300mg/kg loading dose, followed by an additional 100mg/kg) ischemic (n=24 in each group). Transient focal cerebral ischemia was induced by 60-min-long occlusion of the left middle cerebral artery, followed by 24-h-long reperfusion. Sensorimotor deficits, infarct volume, and brain edema were evaluated at the end of the reperfusion period. The BBB permeability was assessed by Evans Blue extravasation technique. Lipid peroxidation levels were assessed by measuring the malondialdehyde content in the brain tissue homogenate, and the activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were detected according to the technical manual of the assay kits. Induction of cerebral ischemia in the control group produced considerable BBB damage in conjunction with severe brain edema formation. Treatment with magnesium sulfate significantly attenuated brain edema and protected BBB integrity in the ischemic lesioned hemisphere. In addition, magnesium sulfate reduced lipid peroxidation and increased antioxidant protection of brain tissue by upregulating the activities of antioxidant enzymes.”

According to the news reporters, the research concluded: “Treatment with magnesium sulfate protected BBB integrity against IR-induced damage and reduced vasogenic edema formation partly via antioxidant mechanisms in a rat model of acute ischemic stroke.”

For more information on this research see: Magnesium Sulfate Protects Blood-brain Barrier Integrity and Reduces Brain Edema After Acute Ischemic Stroke In Rats. Metabolic Brain Disease, 2019;34(4):1221-1229. Metabolic Brain Disease can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer -; Metabolic Brain Disease -

Our news correspondents report that additional information may be obtained by contacting H. Panahpour, Ardabil University of Medical Sciences, School of Medicine, Dept. of Physiology, Ardebil 56197, Iran. Additional authors for this research include J. Shadman, N. Sadeghian, A. Moradi and S. Bohlooli.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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