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Researchers’ Work from Cheng Ching Hospital Focuses on Allergies (The Protective Role of Garlic on Allergen-Induced Airway Inflammation in Mice)

Taiwan Daily Report


2019 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- Investigators publish new report on Immune System Diseases and Conditions - Allergies. According to news originating from Taichung, Taiwan, by NewsRx correspondents, research stated, “Asthma is the most prevalent chronic respiratory disease worldwide. Garlic extracts have long been used as a food source and in traditional medicine.”

Our news journalists obtained a quote from the research from Cheng Ching Hospital, “Crude extracts of garlic are used as an anti-inflammatory agent and have been reported to exhibit antiasthmatic properties. However, molecular mechanisms of garlic extracts in the context of antiasthmatic airway inflammation are still unclear. In this study, the antiasthmatic effect of garlic extracts on Th1, Th2, and Th3 cytokine profiles and immunoregulatory mechanism were explored using an animal model of allergic asthma. Garlic extracts significantly reduced total inflammatory cell counts and eosinophil infiltration and decreased the production of IgE in serum and Th1/Th2/Th3 cytokine in bronchoalveolar fluid. Enzyme-linked immunosorbent assay analysis demonstrated that garlic extracts downregulated the levels of cytokines and chemokines, namely Th2-related IL-4, IL-5, and IL-13; but they simultaneously upregulated Th1-related IFN-, IL-12, and Th3-related IL-10 and TGF-expression in BALF.”

According to the news editors, the research concluded: “The mechanism may be ascribed to the modulation of Th1-, Th2-, and Th3-related cytokine imbalance.”

For more information on this research see: The Protective Role of Garlic on Allergen-Induced Airway Inflammation in Mice. The American Journal of Chinese Medicine, 2019;():1-14. The American Journal of Chinese Medicine can be contacted at: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224.

The news correspondents report that additional information may be obtained from C.C. Hsieh, *Dept. of Medicine Division of Chest Medicine, Cheng Ching Hospital, No 966, Sec 4, Taiwan Road, Taichung, Taiwan. Additional authors for this research include W.H. Peng, H.H. Tseng, S.Y. Liang, L.J. Chen and J.C Tsai.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher’s contact information for the The American Journal of Chinese Medicine is: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224.

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