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Research reports on prostate cancer from University of California, Institute for Human Genetics provide new insights


Investigators publish new data in the report "Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant." According to recent research published in the journal Carcinogenesis, "Previous studies have examined the role of higher trans-fatty acid consumption on prostate cancer risk, but the results remain unclear. Any potential association may be modified by variants in genes involved with immune and inflammatory responses."

"To investigate this, we undertook a case-control study (N12) of the association between trans-fatty acid intake and advanced prostate cancer, and evaluated whether this effect was modified by a functional polymorphism in the RNASEL gene (R462Q). Among Caucasians (N4), we observed that each type of trans-fatty acid and total trans-fatty acid intake showed a statistically significant positive association with prostate cancer, but only weakly increased risk for the isomers of cis-fatty acids. Compared with the lowest quartile of total trans-fatty acid consumption, the higher quartiles gave odds ratios (ORs) equal to 1.58 [95% confidence interval (CI): 1.00, 2.48], 1.95 (95% CI: 1.20, 3.19) and 2.77 (95% CI: 1.60, 4.79) (P-trend=0.0003); this effect was modified by the RNASEL R462Q polymorphism (P(interaction)=0.01). Among men with the QQ/RQ genotype, the association between total trans-fatty acid intake and prostate cancer was substantially stronger [ORs of higher quartiles equal to 2.93 (95% CI: 1.62, 5.30), 3.13 (95% CI: 1.64, 5.98) and 4.80 (95% CI: 2.29, 10.08), respectively]. For men with the RR genotype, total trans-fatty acid intake was not associated with disease," wrote X. Liu and colleagues, University of California, Institute for Human Genetics.

The researchers concluded: "This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q."

Liu and colleagues published their study in Carcinogenesis (Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Carcinogenesis, 2007;28(6):1232-6).

For additional information, contact X. Liu, University of California, Dept. of Epidemiology and Biostatistics and Institute for Human Genetics, San Francisco, CA 94143-0794 USA.

The publisher's contact information for the journal Carcinogenesis is: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England.

Keywords: United States, San Francisco, Carcinogenesis, Clinical Trial Research, Immunization, Oncology, Prostate Cancer, Prostate Cancer Vaccine, Prostatic Neoplasms, Vaccination.

This article was prepared by Drug Week editors from staff and other reports. Copyright 2007, Drug Week via

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