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Scientists at University of Wisconsin, Department of Dermatology describe research in nutrition


Fresh data on nutrition are presented in the report 'Antiproliferative effects of apple peel extract against cancer cells.' "Studies have shown an inverse relationship between the consumption of apples and the risk of several cancers. The peels of apple, which have been shown to possess exceptionally high concentrations of antioxidants, are often discarded," researchers in the United States report (see also Nutrition).

"In this study, we evaluated the antiproliferative effects of apple peel extract (APE) in variety of cancer cell types. Our data demonstrated that APE, obtained from organic Gala apples, imparted significant reduction in the viability of a variety of cancer cell lines. Further, our data showed a significant decrease in growth and clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells and breast carcinoma Mcf-7 and Mcf-7:Her18 cells. Also, the antiproliferative effects of APE were found to be accompanied by a G0-G1 phase arrest of prostate and breast cancer cells. Furthermore, APE treatment resulted in a marked concentration-dependent decrease in the protein levels of proliferative cell nuclear antigen, a marker for proliferation. In addition, APE treatment resulted in a marked increase in maspin, a tumor suppressor protein that negatively regulates cell invasion, metastasis, and angiogenesis. Our data suggested that APE possesses strong antiproliferative effects against cancer cells, and apple peels should not be discarded from the diet," wrote S. Reagan-Shaw and colleagues, University of Wisconsin, Department of Dermatology.

The researchers concluded: "Detailed mechanistic studies, especially in appropriate in vivo animal models, are needed to further examine the antiproliferative and preventive effects of APE against cancer."

Reagan-Shaw and colleagues published their study in Nutrition and Cancer (Antiproliferative effects of apple peel extract against cancer cells. Nutrition and Cancer, 2010;62(4):517-24).

For additional information, contact S. Reagan-Shaw, University of Wisconsin, Dept. of Dermatology, Madison, Wisconsin 53706 USA.

Keywords: City:Madison, State:Wisconsin, Country:United States, Alternative Medicine, Cancer, Carcinoma, Nutrition, Oncology, Therapy, Treatment.

This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2010, Cancer Weekly via

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