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Intervention effects of quercetin against increased NF-kB activity in mice liver caused by intense exercise

Genomics & Genetics Daily

2020 SEP 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- New research on nutrient research is the subject of a new report. According to news originating from Beijing, People’s Republic of China, by NewsRx correspondents, research stated, “Emerging evidence has supported that intensive exercise induces weakened performance and immune and metabolic disorders.”

Financial supporters for this research include National Natural Science Foundation of China-Guangdong Joint Fund.

Our news reporters obtained a quote from the research from National Institute for Nutrition and Health: “We systematically evaluated the effects of quercetin against hepatic inflammatory damage caused by repeated intensive exercise and explored the potential mechanism. Male BALB/c mice were administered quercetin (100 mg/kg BW) for four weeks, and performed a treadmill running protocol of 28 m/min, 5° slope, 90 min/day concurrently for the last seven days. Quercetin administration reduced the leakage of aspartic acid and alanine aminotransferase and improved ultrastructural abnormalities such as swelling, and degeneration caused by high-intensity running in mice. Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1b, IL-6, TNF-a, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise. Furthermore, diminished activation and nuclear translocation of NF-kB were found after quercetin treatment through inhibiting IKKa and Ikba phosphorylation of intensive running mice.”

According to the news editors, the research concluded: “Quercetin offers protection for mouse livers against intensive sports-induced inflammatory injury, and the suppression of the NF-kB signal transduction pathway may play a role in its anti-inflammatory effects. Our findings broaden our understanding of natural phytochemicals as a promising strategy to prevent excessive exercise damage.”

For more information on this research see: Intensive Running Enhances NF-kB Activity in the Mice Liver and the Intervention Effects of Quercetin. Nutrients, 2020,12(2770):2770. (Nutrients - http://www.mdpi.com/journal/nutrients/). The publisher for Nutrients is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/nu12092770.

Our news journalists report that more information may be obtained by contacting Chao Gao, Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, People’s Republic of China. Additional authors for this research include Yang Liu, Chunjie Jiang, Liang Liu, Juan Li, Dan Li, Xiaoping Guo, Zhu Wang, Yuexin Yang, Liegang Liu, Ping Yao, Yuhan Tang.

(Our reports deliver fact-based news of research and discoveries from around the world.)