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Randomized trial that involved participants with mild cognitive impairment found extra virgin olive oil helped improve cognitive function

Mental Health News Daily

2020 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health News Daily -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. According to news reporting originating from Thessaloniki, Greece, by NewsRx correspondents, research stated, “Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function. To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI).”

Our news editors obtained a quote from the research, “We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOEe4) to Alzheimer’s disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions. Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p=0.001) and MMSE (p=0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p=0.003), Digit Span (p=0.006), and Letter fluency (p=0.003). Moreover, there was a significant difference (p=0.001) in the presence of APOEe4 between the Groups 1 and 2 versus Group 3.”

According to the news editors, the research concluded: “Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOEe4.”

This research has been peer-reviewed.

For more information on this research see: A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study. Journal of Alzheimer’s Disease, 2020. Journal of Alzheimer’s Disease can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.

The news editors report that additional information may be obtained by contacting Eftychia Lazarou, Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Makedonia, Greece. Additional authors for this research include Magda Tsolaki, Mahi Kozori, Niki Petridou, Irene Tabakis, Ioulietta Lazarou, Maria Karakota, Iordanis Saoulidis, Eleni Melliou and Prokopios Magiatis.

Publisher contact information for the Journal of Alzheimer’s Disease is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.

(Our reports deliver fact-based news of research and discoveries from around the world.)