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Overconsumption of omega-6 polyunsaturated fatty acids versus deficiency of omega-3s in modern diets

NewsRx Hematology Daily

2021 APR 12 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Hematology Daily -- Research findings on lipid research are discussed in a new report. According to news originating from the Department of Biotechnology by NewsRx editors, the research stated, “Polyunsaturated fatty acids (PUFAs) contain 2 double-bond desaturations within the acyl chain. Omega-3 (n-3) and Omega-6 (n-6) PUFAs are the two known important families in human health and nutrition.”

The news correspondents obtained a quote from the research from Department of Biotechnology: “In both Omega families, many forms of PUFAs exist: a-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) from the n-3 family and linoleic acid (LA), dihomo-g-linolenic acid (DGLA), and arachidonic acid (AA) from the n-6 family are the important PUFAs for human health. Omega-3 and Omega-6 PUFAs are competitively metabolized by the same set of desaturation, elongation, and oxygenase enzymes. The lipid mediators produced from their oxidative metabolism perform opposing (antagonistic) functions in the human body. Except for DGLA, n-6 PUFA-derived lipid mediators enhance inflammation, platelet aggregation, and vasoconstriction, while those of n-3 inhibit inflammation and platelet aggregation and enhance vasodilation. Overconsumption of n-6 PUFAs with low intake of n-3 PUFAs is highly associated with the pathogenesis of many modern diet-related chronic diseases. The volume of n-6 PUFAs is largely exceeding the volume of n-3PUFAs. The current n-6/n-3 ratio is 20-50/1.”

According to the news reporters, the research concluded: “Due to higher ratios of n-6/n-3 in modern diets, larger quantities of LA- and AA-derived lipid mediators are produced, becoming the main causes of the formation of thrombus and atheroma, the allergic and inflammatory disorders, and the proliferation of cells, as well as the hyperactive endocannabinoid system. Therefore, in order to reduce all of these risks which are due to overconsumption of n-6 PUFAs, individuals are required to take both PUFAs in the highly recommended n-6/n-3 ratio which is 4-5/1.”

For more information on this research see: Overconsumption of Omega-6 Polyunsaturated Fatty Acids (PUFAs) versus Deficiency of Omega-3 PUFAs in Modern-Day Diets: The Disturbing Factor for Their “Balanced Antagonistic Metabolic Functions” in the Human Body. Journal of Lipids, 2021,2021. (Journal of Lipids - https://www.hindawi.com/journals/jl/). The publisher for Journal of Lipids is Hindawi Limited.

A free version of this journal article is available at https://doi.org/10.1155/2021/8848161.

Our news editors report that more information may be obtained by contacting Abeba Haile Mariamenatu, Department of Biotechnology.

(Our reports deliver fact-based news of research and discoveries from around the world.)