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Beta-glucan from barley attenuates glycemic response after a meal by inhibiting activities of glucose transporters

Health & Medicine Daily

2021 MAY 04 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Investigators publish new report on diet and nutrition. According to news reporting from Winnipeg, Canada, by NewsRx journalists, research stated, “Beta (b)-glucan (BG) from cereal grains is associated with lowering post-prandial blood glucose but the precise mechanism is not well-elucidated.”

Financial supporters for this research include Agriculture and Agri-Food Canada.

Our news editors obtained a quote from the research from Agriculture and Agri-Food Canada: “The main aim of this study was to understand the mechanism through which BG from barley affects post-prandial glycemic response. Waffles containing 0, 1, 2, and 3 g barley BG and the same amount of available carbohydrate (15 g) were fed to the TIM-1 dynamic gastrointestinal digestion system to study the effect of BG on starch hydrolysis. Intestinal acetone powder and Xenopus laevis oocytes were used to study BG’s effect on mammalian intestinal a-glucosidase and glucose transporters. The presence of BG did not significantly affect the in vitro starch digestion profiles of waffles suggesting that BG does not affect a-amylase activity. Intestinal a-glucosidase and glucose transport activities were significantly (p < 0.0001) inhibited in the presence of barley BG. Interestingly, BG viscosity did not influence a-amylase, a-glucosidase, GLUT2, and SGLT1 activities.”

According to the news editors, the research concluded: “This study provides the first evidence for the mechanism by which BG from barley attenuates post-prandial glycemic response is via alteration of a-glucosidase, GLUT2, and SGLT1 activity, but not amylolysis of starch. The decrease in post-prandial blood glucose in the presence of BG is likely a consequence of the interaction between BG and membrane active proteins (brush border enzymes and glucose transporters) as opposed to the commonly held hypothesis that increased viscosity caused by BG inhibits starch digestion.”

For more information on this research see: Beta-Glucan From Barley Attenuates Post-prandial Glycemic Response by Inhibiting the Activities of Glucose Transporters but Not Intestinal Brush Border Enzymes and Amylolysis of Starch. Frontiers in Nutrition, 2021,8. (Frontiers in Nutrition - http://www.frontiersin.org/nutrition). The publisher for Frontiers in Nutrition is Frontiers Media S.A.

A free version of this journal article is available at https://doi.org/10.3389/fnut.2021.628571.

Our news journalists report that additional information may be obtained by contacting Lovemore Nkhata Malunga, Richardson Center for Functional Foods and Nutraceuticals, Agriculture and Agri-Food Canada, Winnipeg, MB, Canada. Additional authors for this research include Nancy Ames, Haonan Zhouyao, Heather Blewett, Sijo Joseph Thandapilly.

(Our reports deliver fact-based news of research and discoveries from around the world.)