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Antiproteinuria effect of calcitriol in patients with chronic kidney disease and vitamin D deficiency: a randomized controlled study

Taiwan Daily Report

2019 NOV 26 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- Current study results on Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency have been published. According to news reporting originating in Taipei, Taiwan, by NewsRx journalists, research stated, “Vitamin D has been demonstrated to lessen proteinuria severity in chronic kidney disease (CKD). Compared with healthy populations, patients with CKD may have lower serum levels of 1,25-dihydroxy vitamin D (1,25-(OH)2 D) and 25-hydroxy vitamin D (25-(OH) D).”

Financial support for this research came from Tri-Service General Hospital.

The news reporters obtained a quote from the research from Tri-Service General Hospital, “We investigated the effect of oral low-dose active vitamin D (calcitriol at 0.25 mg, 3 times weekly) on urinary protein excretion. We conducted a nonblinded and non-placebo-controlled study. In total, 60 patients with CKD (average estimated glomerular filtration rate of >15 mL/min) who received a stable dose of angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI) were enrolled in this 24-week study. We randomly assigned these patients to the vitamin D group (oral calcitriol at 0.25 mg 3 times weekly with an ACEI or ARB) or the control group (ACEI or ARB). Change in the urine protein/creatinine ratio (uPCR) was the primary endpoint in this study. The mean baseline uPCRs of the 2 groups were comparable (1.84 ? 0.83 g/g vs. 2.02 ? 0.97 g/g, control vs. vitamin D group; p=.46). After the 24-week treatment, the uPCRs were significantly lower than the baseline values in the vitamin D group (1.35 ? 0.64 g/g; p<.05) but not in the control group. The values of uPCR decreased significantly at 8, 16, and 24 weeks (p <.05 vs. baseline) in the vitamin D group. The values of uPCRs were significantly lower in the vitamin D group than in the control group at 8, 16, and 24 weeks (p <.05). A positive correlation was discovered between reduction in uPCRs at 24-week and baseline 25-(OH) D serum level in the vitamin D group (r=0.738, p<.001).”

According to the news reporters, the research concluded: “Supplementary low-dose active vitamin D could reduce proteinuria in CKD patients with low serum 25-(OH) D levels.”

For more information on this research see: Antiproteinuria Effect of Calcitriol in Patients With Chronic Kidney Disease and Vitamin D Deficiency: A Randomized Controlled Study. Journal of Renal Nutrition, 2019;():. Journal of Renal Nutrition can be contacted at: W B Saunders Co, Independence Square West Curtis Center, Ste 300, Philadelphia, PA 19106-3399, USA. (Elsevier - www.elsevier.com; Journal of Renal Nutrition - http://www.journals.elsevier.com/journal-of-renal-nutrition/)

Our news correspondents report that additional information may be obtained by contacting P. Chu, Division of Nephrology, Dept. of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Additional authors for this research include M.T. Liao, P.J. Hsiao, C.L. Lu, Y.J. Hsu, K.C. Lu and P. Chu.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1053/j.jrn.2019.09.001. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the Journal of Renal Nutrition can be contacted at: W B Saunders Co, Independence Square West Curtis Center, Ste 300, Philadelphia, PA 19106-3399, USA.

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