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Palm tocotrienol supplementation associated with beneficial effects in rat model of rheumatoid arthritis

Health & Medicine Daily

2019 DEC 03 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New study results on arthritis have been published. According to news reporting originating from the Malaysian Palm Oil Board by NewsRx correspondents, research stated, “The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities.”

Financial supporters for this research include Malaysian Palm Oil Board PD191/14.

Our news reporters obtained a quote from the research from Malaysian Palm Oil Board: “Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF.”

According to the news editors, the research concluded: “Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA.”

For more information on this research see: Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo. Scientific Reports, 2019,9(1):1-11. (Scientific Reports - http://www.nature.com/srep/index.html). The publisher for Scientific Reports is Nature Publishing Group.

A free version of this journal article is available at https://doi.org/10.1038/s41598-019-53424-7.

Our news journalists report that more information may be obtained by contacting Zaida Zainal, Nutrition Unit, Department of Product Development and Advisory Services (PDAS), Malaysian Palm Oil Board. Additional authors for this research include Afiqah Abdul Rahim, Ammu Kutty Radhakrishnan, Sui Kiat Chang, Huzwah Khaza’ai.

(Our reports deliver fact-based news of research and discoveries from around the world.)