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Menstrual problems in adolescence linked with low vitamin A, E

NewsRx Women’s Health Daily

2019 DEC 04 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women’s Health Daily -- New research on Menstruation Diseases and Conditions - Premenstrual Syndrome is the subject of a report. According to news reporting originating in Mashhad, Iran, by NewsRx journalists, research stated, “Vitamin status and inflammatory mechanisms may be related to menstrual cycle abnormalities. We investigated the associations between serum fat soluble vitamin (vitamins A and E) concentrations and biomarkers of inflammation and antioxidant status with menstrual characteristics, primary dysmenorrhea (PD) and premenstrual syndrome (PMS) in healthy adolescents.”

Financial support for this research came from Mashhad University of Medical Sciences.

The news reporters obtained a quote from the research from the Mashhad University of Medical Sciences, “A total of 897 adolescent girls either suffering from PMS (n=134), PD (n=322), PMS and PD (n=293) or healthy adolescents (n=148) were recruited. Serum vitamin A and E, high-sensitivity C-reactive protein (hs-CRP), antibody titers to Hsp27 (anti-Hsp27), serum prooxidant-antioxidant balance (PAB), WBC, mean platelet volume (MPV), and platelet distribution width (PDW) and RBC distribution width (RDW) were measured. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and RDW-to-platelet ratio (RPR) were calculated. Girls with long bleeding periods had lower concentrations of serum vitamin E compared to those who reported a normal period duration. There were significantly differences between the groups reporting oligomenorrhea, regular menses and polymenorrhea with respect to NLR, RPR, MPV and PDW. Logistic regression demonstrated that the presence of both PMS and PD was positively related to higher serum hs-CRP, PAB and NLR, while serum vitamin A level was inversely related to the presence of PMS. We found that serum vitamin A, hs-CRP, PAB and NLR are significantly associated with the presence of PMS and PD. Inflammatory processes may contribute to the etiology, symptoms and severity of menstrual disorders.”

According to the news reporters, the research concluded: “Prospective studies are needed to elucidate the possibility of targeting oxidative stress and inflammatory process for the amelioration of menstrual symptoms.”

For more information on this research see: Menstrual problems in adolescence: relationship to serum vitamins A and E, and systemic inflammation. Archives of Gynecology and Obstetrics, 2019;():. Archives of Gynecology and Obstetrics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Archives of Gynecology and Obstetrics - http://www.springerlink.com/content/0932-0067/)

Our news correspondents report that additional information may be obtained by contacting H.R. Sadeghnia, Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Additional authors for this research include H. Bahrami-Taghanaki, Z. Khorasanchi, A. Timar, N. Jaberi, E. Azaryan, M. Tayefi, G.A. Ferns, H.R. Sadeghnia and M. Ghayour-Mobarhan.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s00404-019-05343-1. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the journal Archives of Gynecology and Obstetrics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

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