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Meta-analysis finds lower serum vitamin D status associated with greater risk of endometriosis

NewsRx Women’s Health Daily

2020 JUN 01 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women’s Health Daily -- Investigators discuss new findings in Uterine Diseases and Conditions - Endometriosis. According to news reporting out of Sichuan, People’s Republic of China, by NewsRx editors, research stated, “No consensus exists on the relationship between vitamin D status and endometriosis. The chief aim of our study was to evaluate the association between serum vitamin D levels and endometriosis.”

Funders for this research include Sichuan Science and Technology Program, Chengdu Science and Technology Huimin Technology Research and Development Project.

Our news journalists obtained a quote from the research from West China Second University Hospital, “We searched for MEDLINE, EMBASE, and China National Knowledge Infrastructure (CNKI) databases for studies elucidated the circulating vitamin D levels in endometriosis. The standardized mean differences (SMDs) or odds ratios (ORs) with their 95% confidence interval (CIs) were calculated to evaluate the association between vitamin D levels and endometriosis. Nine studies were included in this meta-analysis. The pooled results indicated that women with endometriosis had lower vitamin D status than that in controls (SMD -0.97 ng/mL, 95% CI -1.80 to -0.14; p=0.02), and vitamin D status had a negative correlation with the severity of the disease (stage III-IV vs stage I-II: SMD -1.33 ng/mL, 95% CI -2.54 to -0.12; p=0.03). Although it was not statistically significantly different, hypovitaminosis D had a tendency to be associated with endometriosis (OR 2.77, 95% CI 0.85-6.08, p=0.10). Heterogeneity was high among included studies. Subgroup analyses revealed that women with no hormone use had lower vitamin D status when compared with controls (SMD -1.38 ng/mL, 95% CI -2.59 to -0.18; p=0.02). For studies which sample size <100, serum vitamin D levels were significantly lower in patients than that in controls (SMD -0.65 ng/mL, 95% CI -1.19 to -0.11; p=0.02). Women with endometriosis had lower vitamin D status when compared with controls, and a negative relationship between vitamin D levels and severity of endometriosis was observed.”

According to the news editors, the research concluded: “In addition, hypovitaminosis D was a potential risk factor for endometriosis.”

For more information on this research see: Vitamin D status in endometriosis: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 2020;():. Archives of Gynecology and Obstetrics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Archives of Gynecology and Obstetrics - http://www.springerlink.com/content/0932-0067/)

Our news journalists report that additional information may be obtained by contacting S. Yuan, Dept. of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China. Additional authors for this research include Y. Qiu and H. Wang.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s00404-020-05576-5. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Archives of Gynecology and Obstetrics is: Springer, 233 Spring Street, New York, NY 10013, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)