Menopause 731™
Put a pause to the cause

with Menopause 731™

Menopause is a natural part of a woman's life cycle — but not necessarily a pleasant one. Menopause 731™ Siberian rhubarb extract helps relieve 11 discomforts of menopause: hot flashes, night sweats, irritability, mood swings, sleep disturbances, exhaustion, joint and muscle discomfort, vaginal dryness, urinary health, and sexual function. It's comprehensive menopause relief.


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Siberian Rhubarb Extract:
Plant-Based. Effective.

While still relatively unknown in the United States, Siberian rhubarb (R. rhaponticum) has been used successfully in Germany to manage the discomforts of menopause since the early 1990s.

Menopause 731™ contains a Siberian rhubarb extract standardized for two unique compounds: rhaponticin and desoxyrhaponticin. In a pre-clinical study, these compounds selectively activated a specific estrogen receptor, ER-ß, while leaving the ER-α receptor alone.1

Scientists believe this is why Siberian rhubarb is so effective at relieving menopausal discomfort.

Siberian rhubarb plant

Wild Siberian rhubarb
(Rheum rhaponticum)

ER-α and ER-ß:
What's the Difference?

Estrogen Receptor–Alpha: ER-α

Estrogen receptor–alpha is primarily located in female reproductive tissue.

ER-α affects reproductive tissue when activated — something that is best avoided after menopause.

Estrogen Receptor–Beta: ER-ß

Estrogen receptor–beta is primarily found in women's non-reproductive tissues.

ER-ß produces non-reproductive effects that sustain tissue health, flexibility, and function.

Estrogen Receptors and Menopause

Menopause signals a decline in estrogen production. So when it comes to addressing the discomforts of menopause, the established protocol is to somehow maintain healthy estrogen levels.

Activating ER-beta benefits the parts of your physiology most affected by menopause, promoting healthy biological reactions that benefit your skin, heart, emotions and more — stuff that used to be regulated by your body's natural estrogen.

Woman with coffee
Menopause 731™

Easing Menopause Discomfort

Menopause 731™ activates estrogen receptor ER-beta for powerful relief from a wide variety of menopause-related complaints:

Hot flashes
Night sweats
Mood swings
Sleep disturbances
Joint & muscle discomfort
Vaginal dryness
Urinary health
Sexual function
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Real Women,
Real Results:
Clinical Studies

Siberian rhubarb has been clinically evaluated in over 400 women. Results were measured by self-reported answers on the Menopause Rating Scale (MRS), a standardized research questionnaire designed to evaluate experienced menopausal discomfort, as well as a specialized survey that rates patients' mood and emotional health.

Clinical results show significant relief for 11 distinct menopause discomforts, especially for women experiencing hot flashes, night sweats, irritability, and mood swings. Remarkably, study participants reported improvement in all of their discomforts, including sleep disturbances, exhaustion, joint and muscle discomforts, and vaginal dryness, as well as urinary and sexual health.

Bar graph showing decreased menopause symptoms within 3 and 6 months of use

Decrease of the MRS Total Score (mean ± SD) in women from baseline to 3 and 6 months of use with ERr 731®

*P<.0001 (highly significant)

Altern Ther Health Med. 2008 Nov-Dec;14(6):32-8.

Dr. Crystal Gossard

Dr. Crystal M. Gossard, DCN, CNS, LDN
Doctor of Clinical Nutrition, Life Extension Clinical Information Team

Clinical Nutrition Expert


Menopausal discomforts can start in our late 30s and can last for many years after menopause.

In clinical studies, Siberian rhubarb extract has been shown to provide comprehensive relief from 11 common menopausal discomforts.


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Our formulas have the same ingredients and dosages as the studies that inspired them. The right ingredients, in the right amounts, give you the optimal health benefits.

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So why choose Life Extension? Because your body deserves the best.

Satisfaction Guarantee
Put a pause to the cause

with Menopause 731™

Menopause 731™ delivers 4 mg of the same Siberian rhubarb extract clinically shown to relieve 11 discomforts of menopause. It provides convenient, once-daily menopause relief.

Try Menopause 731™ today!


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Menopause 731™

Frequently Asked Questions
about Menopause 731™:

Does Menopause 731™ use the same dosage and ingredients as the clinical studies?
YES. The dosage of ERr 731® Siberian rhubarb (Rheum rhaponticum) extract was chosen based on clinical studies that surveyed over 400 women.

When will Menopause 731™ begin to relieve my discomforts of menopause?
Based on the study (Heger, 2006), Siberian rhubarb extract can begin to relieve menopausal discomforts in as little as four weeks, with the best results seen after 12 weeks. Additionally, studies indicate positive results continuing from six months to over two years.

Do I need to eat cruciferous vegetables or apply a natural progesterone cream with this product?
Based on the extensive clinical data, there is no need to take Menopause 731™ in conjunction with cruciferous vegetables or use a natural progesterone cream. However, there's no reason not to eat cruciferous vegetables or utilize a natural progesterone cream — especially if you're looking to optimize your estrogen metabolite ratio or achieve other benefits of a progesterone cream.

Can I take Menopause 731™ in addition to bioidentical hormone replacement therapy?
NO. If you are currently using BHRT or other hormone treatment, you should not add to or subtract from your regimen without first consulting your prescribing physician.

†Ratings based on results of the 2018 Survey of Supplement Users. More information at

**If you are not 100% satisfied with any purchase made directly from Life Extension®, simply return your purchase. Most products may be returned within 12 months of the original purchase date, but some exclusions apply. Once we have received your return, we will gladly replace the product for you, credit your original payment method, or credit your Life Extension account for the full amount of the original purchase price (less shipping). Any LE Dollars earned on returned product will be debited from your rewards account. If you cancel your Premier Rewards service, you will receive a refund of the unused portion of the enrollment cost and any remaining product credit will be debited from your account.

ERr 731® is a registered trademark of Chemisch-Pharmzeutische Fabrik Göppingen Carl Müller Apotheker GmbH & Co.

1. Menopause. 2014 Dec; 21(12):1320–69 exhibit P-11

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.