Alpha Lipoic Acid

  • 100 mg, 60 tablets
  • Item # 28254

Alpha Lipoic Acid

  • 100 mg, 60 tablets
  • Item # 28254

Jarrow FORMULAS® Alpha-Lipoic Acid (ALA) is a unique lipid and water soluble antioxidant that is a cofactor in energy production, helping to regulate glucose metabolism. Alpha-lipoic acid also promotes the synthesis of glutathione. Biotin is an essential cofactor that is important for energy production and lipid metabolism.  Biotin is added for optimum ALA activity.

Alpha-lipoic acid is used in Europe to promote liver and nerve health, and confer protective benefits against oxidative processes. Alpha-lipoic acid has been called the “universal” antioxidant because it boosts glutathione levels in cells and has potent antioxidant actions.1-3 Research has strongly implicated cellular oxidative damage caused by free radicals as a cause of many degenerative problems. What makes alpha-lipoic acid so effective as an antioxidant is its ability to quench free radicals in both aqueous and lipid environments. This means that the antioxidant activity of alpha-lipoic acid is working in the extra-cellular fluid and also within the cell. It also has metal chelating ability, helping the body rid itself of accumulated ingested toxins.4-7

Alpha-lipoic acid also is a co-factor for some of the key enzymes (alpha keto acid dehydrogenases) involved in generating energy from food and oxygen in mitochondria8-10 and thus plays a critical role in energy production within the cell’s mitochondria.8,9,11

One of the most beneficial effects of alpha-lipoic acid is its ability to regenerate other essential antioxidants such as vitamins C and E, coenzyme Q10, and glutathione, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). The evidence is especially strong for the ability of DHLA (dihydro-lipoic acid, a reduced form of alpha-lipoic acid) to recycle vitamin E. This is apparently achieved directly by quenching tocopherol radicals or indirectly by reducing vitamin C or increasing the levels of ubiquinol (a derivative of CoQ10) and glutathione, that, in turn, helps regenerate tissue levels of vitamin E.8,12-18

In clinical studies to date with alpha-lipoic acid, there have been no reported serious adverse side effects, even at high doses. Among the mild, reversible side effects found in some patients have been allergic skin reactions and possible hypoglycemia in diabetics.

  References
 1. J Appl Physiol. 1999 Apr;86(4):1191-6.
  2. Chem Biol Interact. 2006 Nov 7;163(3):192-8.
  3. Nutrition. 2007 Jan;23(1):76-80.
  4. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1395-403.
  5. Pharmacol Ther. 2007 Jan;113(1):154-64.
  6. Toxicol Lett. 2005 Dec 30;160(1):1-7.
  7. Chem Biol Interact. 2004 Apr 15;147(3):259-71.
  8. Chem Biol Interact. 2001 Nov 28;138(2):189-98.
  9. Neurochem Res. 2007 Sep;32(9):1552-8
10. Drug Metab Rev. 1998 May;30(2):245-75.
11. Ann N Y Acad Sci. 2002 Apr;959:491-507
12. Free Radic Biol Med. 1997;22(1-2):359-78.
13. Free Radic Biol Med. 2001 Jul 1;31(1):53-61.
14. Z Naturforsch [C]. 1998 Mar-Apr;53(3-4):250-3.
15. Nutrition. 2001 Oct;17(10):888-95.
16. Gen Pharmacol. 1997 Sep;29(3):315-31.
17. Biochim Biophys Acta 1988 Dec 16;963(3):558-61
18. Biochem Biophys Res Commun 1990 Jun 29;169(3):851-7

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Serving Size 1 tablet

Servings Per Container 60

Amount Per Serving

Biotin

333 mcg

Alpha Lipoic Acid (Thioctic Acid)

100 mg

Other ingredients: Calcium phosphate, cellulose, modified cellulose gum, stearic acid (vegetable source), magnesium stearate (vegetable source), silicon dioxide and vanilla. 

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Dosage and Use

Take one to six tablets per day, preferably with meals, or as directed by your qualified health care consultant. Easy-Solv® tablets are designed to disintegrate within several minutes of ingestion.

Warnings

If you have a medical condition (especially diabetes or being treated for glucose control), are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially for glucose control), consult your health care practitioner before using this product.

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Alpha Lipoic Acid

100 mg, 60 tablets

$8.96

$0.15/count | 10 - 60 Day Supply