High dose multivitamin and mineral supplementation associated with fewer cardiac events in non-statin users following heart attack
January 16, 2018
The January 2018 issue of American Heart Journal reported the finding of a randomized trial of a reduction in cardiac events and mortality from any cause over follow-up in association with high dose vitamin and mineral supplementation among patients with a history of heart attack who were not being treated with statin drugs.
The Trial to Assess Chelation Therapy (TACT) was a double-blind investigation conducted at U.S. and Canadian sites that enrolled 1,708 participants between September 2003 and October 2010. The participants, who had a history of heart attack at least 6 weeks prior to enrollment, received a series of 40 chelation therapy or placebo infusions. Each group also received six tablets daily of a high dose orally administered vitamin and mineral supplement or an oral placebo for the duration of the trial. The supplement provided vitamins A, C, D3, E, K1, B1, B3, B5 and B6, folate, PABA, choline, inositol, biotin, calcium, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, potassium, boron, vanadium and citrus bioflavonoids.
Among the 460 participants who were not being treated with statin drugs at enrollment, 137 either died (from any cause) or experienced a major adverse cardiac event such as heart attack, stroke, coronary revascularization, or hospitalization for angina over a median follow-up of 55 months. For non-statin users who received multivitamins and minerals, the risk of one of these outcomes was 38% lower compared to those who received an oral placebo. Mortality from any cause over follow-up was 53% lower in the supplemented group.
Participants who received the vitamins and minerals also experienced a 54% lower risk of the study’s secondary end point of cardiovascular mortality, stroke or recurrent heart attack. When cardiovascular mortality alone was considered, vitamin and mineral supplementation was associated with a 61% decrease in risk.
In their discussion of the findings, Omar M. Issa, DO, and colleagues note that no clinical practice guideline currently recommends the use of vitamin supplements to prevent cardiovascular disease, however, the majority of the studies upon which the recommendations are based had tested moderate doses of only a small number of supplements (usually vitamins A, B12, C and E, and folic acid and selenium). "The drug therapy model used by these studies is useful for studying single agents to determine their effectiveness for specific clinical applications but do not extend well to the more complex multicomponent therapies increasingly used for self-care by large numbers of the general population together with many patients with diverse illnesses," they write.
They add that the current findings are being retested in the ongoing TACT2 investigation.
When taking charge of your health, "winging it" is not ideal. You'll need to carefully choose the right supplements to provide your body with only the best! Not sure what supplements are right for you? Don't go it alone … our Supplement Guide is here to help.
Our Supplement Guide is an interactive tool where you give simple, confidential answers to pertinent questions that focus on your overall health and current lifestyle. You'll be guided through the entire process and at the end have a personalized supplement regimen suggested to you via email. Our Supplement Guide is designed to help you steer your health in the right direction. Once you get started, you can always make adjustments to further optimize your nutritional supplement regimen. Visit our Supplement Guide today.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.