CoQ10 supplementation associated with reduced migraine frequency, severity, duration in women
January 30, 2018
An article appearing on January 3, 2018 in Nutritional Neuroscience describes a randomized, double-blind, placebo-controlled trial that resulted in a reduction in migraine duration, frequency and severity, as well as lower levels of calcitonin gene-related peptide (CGRP) and tumor necrosis factor-alpha (a marker of inflammation) among participants who received daily supplements of coenzyme Q10 (CoQ10).
The trial included 45 women aged 18 to 50 years diagnosed with episodic migraine. In addition to migraine prophylactic medication, 23 participants received 400 milligrams CoQ10 per day and 22 participants received a placebo for three months. Serum CoQ10, CGRP, tumor necrosis factor-alpha (TNF-a), and other factors were measured at the beginning and end of the study.
Migraine severity, duration, and frequency per month were lower at the end of the study among those who were given CoQ10 compared to the placebo. In addition to a rise in serum CoQ10 levels, women who received CoQ10 experienced a reduction in TNF-a and CGRP at the end of the treatment period. “There is a correlation between neurologic inflammation and CGRP release in migraine,” Monireh Dahri and colleagues explain. "Likewise, CGRP transcription can be stimulated by endogenous inflammatory molecules, such as TNF-a, which increases the CGRP promoter activity and actuates MAPK pathway. In our study, reduction of TNF-a in CoQ10 treated group was accompanied with CGRP decrease, which can be explained by the above-mentioned mechanism."
"As migraine patients have higher level of inflammation and have been reported to have CoQ10 deficiency, CoQ10 supplementation may be a beneficial complementary treatment in migraineurs," they suggest.
When taking charge of your health, "winging it" is not ideal. You'll need to carefully choose the right supplements to provide your body with only the best! Not sure what supplements are right for you? Don't go it alone … our Supplement Guide is here to help.
Our Supplement Guide is an interactive tool where you give simple, confidential answers to pertinent questions that focus on your overall health and current lifestyle. You'll be guided through the entire process and at the end have a personalized supplement regimen suggested to you via email. Our Supplement Guide is designed to help you steer your health in the right direction. Once you get started, you can always make adjustments to further optimize your nutritional supplement regimen. Visit our Supplement Guide today.
Life Extension Magazine® February 2018 Issue Now Online
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.